Preparation and investigation of a novel iodine-based visible polyvinyl alcohol embolization material  

作　　者：Yupeng Yang Rui Yang Beilei Zhang Ye Tian Yanqi Lu Xiao An Xiangyang Shi 

机构地区：[1]State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine,College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai 201620,China [2]Department of Pharmacy,Zhengzhou Railway Vocational&Technical College,Shanghai 00080,China [3]Department of Neoplasms and Interventional Radiology,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Zhengphou,451460,China

出　　处：《Journal of Interventional Medicine》2022年第2期72-78,共7页介入医学杂志（英文）

基　　金：the State Key Laboratory forModification of Chemical Fibers and Polymer Materials,Donghua University;the Science and Technology Commission of Shanghai Municipality(19XD1400100 and 20520710300);the 2019th Shanghai Medical Guide Science and Technology Supporting Project(19411971000);the Science and Technology Research Project from the Science and Technology Department of Henan Province in 2020(202102310539)。

摘　　要：Polyvinyl alcohol(PVA) embolization particles, currently used in clinical practice, have good expansibility and are capable of permanent embolization. However, the lack of adhesion of embolization particles contributes to facilitated recanalization after embolization, while the lack of visualization facilitates misembolization. At present, embolization materials with good expansion, adhesion, and visualization potential are urgently required in clinical practice. Here, we report the development of PVA/gelatin/iohexol(I) fiber blocks as a novel embolization material for liver embolization in rats. In our work, electrospun PVA/gelatin/I nanofibrous mats were first prepared, homogenized, centrifuged in a gradient manner, and freeze-dried to obtain fiber blocks(fiber diameter =296.2 ± 74.23 nm, length 99.6 ± 17.0 μm × width 46.9 ± 13.3 μm). The fiber blocks exhibited excellent cytocompatibility and hemocompatibility. Fiber blocks with a PVA/gelatin/I mass ratio of 8:2:10 were selected due to their excellent expansibility and adhesive properties. The PVA/gelatin/I fiber blocks display excellent liver embolic effects and computed tomography(CT) imaging potential due to a combination of the following characteristics: expansibility of PVA and gelatin, adhesive property of gelatin, and CT imaging potential of I. The developed fiber block material is an embolic material that may potentially be used in interventional medicine.

关 键 词：ELECTROSPINNING PVA/Gelatin/I embolic material Fiber blocks Visualization EMBOLIZATION 

分 类 号：R318.08[医药卫生—生物医学工程]