党参对慢性阻塞性肺疾病模型小鼠炎症介质的影响  

Therapeutic Effects of Codonopsis Radix on the Mouse Model of Chronic Obstructive Pulmonary Disease

作　　者：郭鹏翔 杨扶德[1] 王志旺[1] 庞亚蓉 丁茂鹏 韦凌霞 GUO Pengxiang;YANG Fude;WANG Zhiwang;PANG Yarong;DING Maopeng;WEI Lingxia(Gansu University of Chinese Medicine,Lanzhou 730000,China;Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730020,China)

机构地区：[1]甘肃中医药大学,兰州730000 [2]甘肃中医药大学附属医院,兰州730020

出　　处：《世界中医药》2022年第20期2847-2850,2859,共5页World Chinese Medicine

基　　金：科技部国家重点研发计划“中医药现代化研究”重点专项(2018YFC1706305)。

摘　　要：目的:研究党参对慢性阻塞性肺疾病(COPD)模型小鼠的治疗作用及对炎症介质的影响。方法:采用经鼻滴注COPD造模液的方法复制COPD小鼠模型,经受试药干预,观测COPD小鼠行为学、肺组织湿干重比值、肺组织中炎症介质白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)及核因子κB的变化,研究党参对COPD的治疗作用及其机制。结果:10.4 g/kg、5.2 g/kg、2.6 g/kg党参可明显改善小鼠抓鼻、挠痒及呼吸异常等COPD行为学,降低肺组织湿干重比值及IL-1β、IL-6、IL-8含量,下调肺组织核因子κB的表达水平(P<0.05,P<0.01)。结论:党参具有治疗COPD的作用,下调炎症介质表达而缓解气道炎症是其作用机制之一。Objective:To study the therapeutic effects of Codonopsis Radix on chronic obstructive pulmonary disease(COPD) and its effect on inflammatory factors in the mouse model of COPD.Methods:The mouse model of COPD was replicated by the nasal drip of COPD-establishing liquid, and the changes in behavior, lung wet/dry weight ratio, and inflammatory factors [interleukin-1β(IL-1β),interleukin-6(IL-6),interleukin-8(IL-8),and nuclear factor kappa B(NF-κB)] in the mouse model of COPD were observed after trial drug intervention.The therapeutic effects of Codonopsis Radix on mice with COPD and its mechanism were studied.Results:The 10.4 g/kg, 5.2 g/kg, and 2.6 g/kg Codonopsis Radix significantly improved the COPD behaviors of mice such as scratching nose, scratching, and abnormal respiration, reduced lung wet/dry weight ratio and the content of IL-1β,IL-6,and IL-8,and down-regulated the expression levels of NF-κB in the lung tissue(P<0.05,P<0.01).Conclusion:Codonopsis Radix has therapeutic effects on COPD,and one of its mechanisms is to down-regulate the expression of inflammatory factors and alleviate airway inflammation.

关 键 词：党参 慢性阻塞性肺疾病 小鼠 炎症介质 核因子ΚB 细胞因子 治疗作用 肺组织 

分 类 号：R285.5[医药卫生—中药学] R562.5[医药卫生—中医学]