烟酸缺乏症14例临床分析  

Clinical analysis of 14 cases of niacin deficiency

作　　者：徐西光[1] 姜菲 杨纯丽 孙心君[1] 田中华[1] 卢彬[1] Xu Xiguang;Jiang Fei;Yang Chunli;Sun Xinjun;Tian Zhonghua;Lu Bin(Department of Dermatology,Affiliated Hospital of Jining Medical University,Jining 272029,China)

机构地区：[1]济宁医学院附属医院皮肤科,济宁272029

出　　处：《中华全科医师杂志》2022年第10期978-980,共3页Chinese Journal of General Practitioners

摘　　要：回顾性分析2012—2021年济宁医学院附属医院皮肤科诊治的14例烟酸缺乏症患者资料。14例年龄26~65岁,其中男性11例、女性3例。病因分别为嗜酒8例、有胃肠道病史者3例、有服药史者1例,2例病因不明;14例均有典型皮损,1例同时合并消化系统及神经系统症状,3例合并消化系统症状,2例合并神经系统症状。均系统行烟酰胺及复合维生素B口服治疗及外用药物治疗,治疗14~52 d后均好转。定期随访,其中2例嗜酒者及1例腹泻患者曾复发。提示,烟酸缺乏症的临床典型三联征不常见,诊断根据病史、临床表现及相关实验室检查结果,烟酰胺及复合维生素B治疗有效;男性患者嗜酒为主要病因,且易复发。The clinical data of 14 patients with niacin deficiency diagnosed and treated in Department of Dermatology, Affiliated Hospital of Jining Medical College from 2012 to 2021 were retrospectively analyzed. There were 11 males and 3 females aged 26-65 years. The etiological factors were alcoholism in 8 cases, gastrointestinal disease in 3 cases, medication history in 1 case, and unknown etiology in 2 cases.Patients had typical skin lesions, 1 case also had both digestive system and nervous system symptoms, and 3 cases had combined digestive system symptoms and 2 cases had neurological symptoms. All patients were systematically treated with oral nicotinamide and vitamin B complex, and also with topical drugs;and they all improved after 14-52 days of treatment. During regular follow-up, 2 cases of alcoholics and 1 case with diarrhea had recurrence. It is suggested that the typical clinical triad of niacin deficiency is uncommon, and the diagnosis is based on the medical history, clinical manifestations and relevant laboratory test, and the treatment with nicotinamide and vitamin B complex is usually effective;alcoholism is the main cause in male patients and is prone to recurrence.

关 键 词：维生素缺乏症 烟酸 嗜酒 烟酰胺 

分 类 号：R591[医药卫生—内科学]