箱式给氧在新生儿呼吸窘迫综合征治疗中的效果分析  

The effect of box oxygen in the treatment of neonatal respiratory distress syndrome

作　　者：刘刚[1] 何荣香 梁道琼 赖思燕 李洪[4] 李顺品[3] Liu Gang;He Rongxiang;Liang Daoqiong;Lai Siyan;Li Hong;Li Shunpin(Newborn Intensive-Care Unit,the Second People's Hospital of Panzhihua,Sichuan 617065)

机构地区：[1]四川省攀枝花市第二人民医院新生儿重症科,617065 [2]四川省攀枝花市第二人民医院新生儿科,617065 [3]四川省攀枝花市第二人民医院儿科,617065 [4]四川省攀枝花市第二人民医院检验科,617065

出　　处：《山西医药杂志》2022年第15期1701-1705,共5页Shanxi Medical Journal

基　　金：四川省攀枝花市科技计划项目(2016ZD-S-2)。

摘　　要：目的探讨箱式给氧在新生儿呼吸窘迫综合征(NRDS)治疗中的效果及对氧合指数(OI)、呼吸指数(RI)、气道炎症与安全性的影响。方法选取2017年6月至2020年6月我院87例NRDS患儿,根据治疗方案分为对照组43例和观察组44例。对照组采取头罩吸氧,观察组采取箱式给氧。统计2组临床疗效、康复指标、不良事件及治疗前后动脉血气指标[吸入氧浓度(FiO_(2))、动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))]、氧合指数(OI)、呼吸指数(RI)、气道炎症因子[人克拉拉细胞分泌蛋白(CC-16)、微小RNA(miR)-155、miR-143]。结果观察组治疗总有效率91%高于对照组70%,且差异有统计学意义(P<0.05);观察组治疗后PaCO_(2)、FiO_(2)、OI、RI及CC-16、miR-155、miR-143低于对照组,PaO_(2)高于对照组(P<0.05);观察组用氧时间、机械通气时间、住院时间短于对照组,且差异有统计学意义(P<0.05);观察组不良事件发生率5%和对照组12%比较,差异无统计学意义(P>0.05)。结论箱式给氧治疗NRDS效果显著,可减轻气道炎症,下调RI、OI,缩短康复进程,且安全性较高。Objective To investigate the effect of box oxygen in the treatment of neonatal respiratory distress syndrome(NRDS)and its influence on oxygenation index(OI),respiratory index(RI),airway inflammation and safety.Methods A total of 87 children with NRDS in our hospital from June 2017 to June 2020 were selected and divided into control group(n=43)and observation group(n=44)according to the treatment plan.The control group used hoods for oxygen inhalation,and the observation group used box-type oxygen.Statistics of clinical efficacy,rehabilitation indicators,adverse events and arterial blood gas indicators before and after treatment[inhaled oxygen concentration(FiO_(2)),arterial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2))],oxygenation index(OI),respiratory index(RI),airway inflammatory factors[human Clara cells secrete protein(CC-16),microRNA(miR)-15,miR-143].Results The total effective rate of the observation group(91%)was higher than that of the control group(70%),and the difference was significant(P<0.05).PaCO_(2),FiO_(2),OI,RI,CC-16,miR-155,miR-143 after treatment in the observation group were lower the those in the control group,while PaO_(2) was higher than that in the control group(P<0.05).The observation group′s oxygen time,mechanical ventilation time,and hospital stay were shorter than those of the control group,and the differences were significant(P<0.05).The incidence of adverse events in the observation group was 5%,and there was no statistically significant difference between the observation group and the control group(P>0.05).Conclusion Box oxygen therapy has a significant effect on the treatment of NRDS,which can reduce airway inflammation,lower RI and OI,and shorten the rehabilitation process.

关 键 词：呼吸窘迫综合征 新生儿 箱式给氧 头罩吸氧 呼吸指数 氧合指数 

分 类 号：R722.1[医药卫生—儿科]