高原睡眠障碍发生机制及其防治药物  

Mechanism,Preventive and Therapeutic Drugs for Sleep Disorders in Plateau

作　　者：王椿清 焦文成 杜丽娜[1,2] WANG Chunqing;JIAO Wencheng;DU Lina(School of Parmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing 100850,China)

机构地区：[1]山东中医药大学药学院,济南250355 [2]军事科学院军事医学研究院辐射医学研究所,北京100850

出　　处：《医药导报》2022年第12期1816-1821,共6页Herald of Medicine

基　　金：北京自然科学基金面上项目(7202147)。

摘　　要：高原缺氧环境对人类睡眠质量有重要影响,急进高原容易发生睡眠障碍。高原环境睡眠障碍主要体现为睡眠结构中慢波睡眠减少,睡眠连续性被破坏,睡眠过程中血氧饱和度、呼吸、血压等生理指标改变。改善高原睡眠障碍除了采用针灸和经颅微脉冲刺激等物理方法外,药物干预具有重要作用。本文概括了高原睡眠障碍发生机制、预防与治疗药物,为建立高原睡眠障碍有效防治措施提供参考。The hypoxia environment at high altitudes has an important effect on human sleep quality.People who are new to the plateau quickly or have lived there for a long time can have sleep disorders.The plateau influence on sleep mainly includes the decrease of slow wave sleep,the destruction of sleep continuity,and some physiological indexes,such as blood oxygen saturation,respiration,and blood pressure during sleep.Besides the physical techniques to improve sleep quality,such as acupuncture and transcranial micro pulse stimulation,the preventive and therapeutic effects of drugs are very important.The review summarizes the and mechanisms of sleep disorders,the preventive and therapeutic drugs.It will provide consultancy for the efficient preventive and therapeutic effects to alleviate sleep disorders in the plateau.

关 键 词：高原睡眠障碍 认知障碍 缺氧 

分 类 号：R971.3[医药卫生—药品]