膜荚黄芪化学成分研究  

Chemical Constituents of Astragalus membranaceus

作　　者：禹建芳 赵江源[2] 杨智明 马建龙[3] 李铭刚[2] 刘世巍[1] 丁建海[1] YU Jian-fang;ZHAO Jiang-yuan;YANG Zhi-ming;MA Jian-long;LI Ming-gang;LIU Shi-wei;DING Jian-hai(College of Chemistry and Chemical Engineering,Ningxia Normal University,Guyuan 756000,China;School of Life Sciences,Yunnan University/Yunnan Institute of Microbiology,Kunming 650091,China;College of Chemistry and Chemical Engineering,Ningxia University,Yinchuan 750021,China)

机构地区：[1]宁夏师范学院化学化工学院,宁夏固原756000 [2]云南大学生命科学学院/云南省微生物研究所,云南昆明650091 [3]宁夏大学化学化工学院,宁夏银川750021

出　　处：《中药材》2022年第2期341-345,共5页Journal of Chinese Medicinal Materials

基　　金：固原市科技计划项目(2018GYYQ0007,2020GYKYF013,2020GYKYF009);固原市人才项目(2019GYSZZB1202);宁夏重点研发计划项目(2019BDE03009,2019BFH02005);宁夏师范学院2020年一流本科课程建设培育项目(分析化学);2020年度“大学生科技创新基金”项目(Z202012);2021年大学生创新创业训练计划项目(X202110753012X)。

摘　　要：目的:研究膜荚黄芪Astragalus membranaceus(Fisch.)Bge.的化学成分。方法:利用各种色谱方法对膜荚黄芪乙醇提取物进行分离纯化,通过理化常数和波谱数据分析鉴定所得化合物的结构。结果:从中分离得到13个化合物,分别鉴定为:(3R)-7,2′-二羟基-3′,4′-二甲氧基异黄烷(1)、毛蕊异黄酮(2)、(6αR,11αR)-10-羟基-3,9-二甲氧基紫檀烷(3)、乙酰黄芪皂苷(4)、lupenone(5)、(3R)-8,2′-二羟基-7,4′-二甲氧基异黄烷(6)、butyl 1H-imidazole-4-carboxylate(7)、(3R)-2′-羟基-3′,4′-二甲氧基异黄烷-7-O-β-D-葡萄糖苷(8)、9,10-二甲氧基紫檀烷-3-O-β-D-吡喃葡萄糖苷(9)、3-羟基-9,10-二甲氧基紫檀烷(10)、(3R)-7,2′,3′-三羟基-4′-甲氧基异黄烷(11)、liquiritigenin(12)、邻苯二甲酸-双(2′-乙基庚基)酯(13)。结论:其中,化合物5、7、13为首次从黄芪属植物中分离得到,化合物1、5、7、8、13为首次从膜荚黄芪中分离得到。Objective:To study the chemical constituents from the roots of Astragalus membranaceus.Methods:The ethanol extract of Astragalus membranaceus was isolated and purified by various chromatographic methods.The structures of the compounds were identified by physicochemical constants and spectral data.Results:Thirteen compounds were isolated from Astragalus membranaceus and identified as(3R)-7,2′-dihydroxy-3′,4′-dimethoxyisoflavan(1),calycosin(2),(6αR,11αR)-3,9-dimethoxy-10-hydroxy-pterocarpan(3),acetytastragaloside(4),lupenone(5),(3R)-8,2′-dihydroxy-7,4′-dimethoxyisoflavan(6),butyl 1 H-imidazole-4-carboxylate(7),(3R)-2′-hydroxy-3′,4′-dimethoxyisoflavan-7-O-β-D-glucoside(8),9,10-dimethoxypterocarpan-3-O-β-D-glucopyranoside(9),9,10-dimethoxy-3-hydroxypterocarpa(10),(3R)-7,2′,3′-trihydroxy-4′-methoxyisoflavan(11),liquiritigenin(12),phthalate-bis(2′-ethyl heptyl)ester(13),respectively.Conclusion:Amomg them,compunds 5,7,13 are isolated from Astragalus genus for the first time,compunds 1,5,7,8,13 are isolated from Astragalus membranaceus for the first time.

关 键 词：膜荚黄芪 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]