基于“气虚痰瘀”探讨心肌微循环障碍防治新进展  

New Progress in the Prevention and Treatment of Myocardial Microcirculation Disorders Based on“Qi Deficiency and Phlegm Stasis”

作　　者：韦娟 何贵新[2] 林琳[2] 秦伟彬 玉黎燕 冯雨菲 胡梦弦 甲子永 文琦 WEI Juan;HE Guixin;LIN Lin;QIN Weibin;YU Liyan;FENG Yufei;HU Mengxian;JIA Ziyong;WEN Qi(Guangxi University of Chinese Medicine,Nanning 530001,Guangxi,China;The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530022,Guangxi,China)

机构地区：[1]广西中医药大学,广西南宁530001 [2]广西中医药大学第一附属医院,广西南宁530022

出　　处：《辽宁中医药大学学报》2022年第10期73-77,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金地区基金项目(81960861);广西科学重点研发计划项目(桂科AB19110006);广西高校中青年教师科研基础能力提升项目(2020KY07026)。

摘　　要：微循环完整性的缺失和未再通会使部分患者心肌组织无灌注或灌注不良,并形成微血管栓塞,引发冠状动脉微循环障碍。冠状动脉微循环受损被认为是决定冠心病预后的独立危险因素。冠心病的标化死亡率仍呈上升态势,如何更好地改善心肌微循环障碍是当今心血管研究领域所面临的非常重要并且亟待解决的问题。作者从病理生理学角度初步认识心肌微循环障碍的发病机制,从中医学角度简述该疾病的致病特点及中医学机制,寻找该疾病的切入点。中药药理作用具有多层次、多靶点、多指向、多覆盖的特点,被广泛地应用到心肌微循环障碍临床治疗。该文立足“气虚痰瘀”理论积极探索心肌微循环障碍的病因、病机和防治规律,对于提高该病的中西医结合防治研究水平具有重要意义。The lack of microcirculation integrity and recanalization will lead to non-perfusion or poor perfusion of myocardial tissue in some patients,and the formation of microvascular embolism will lead to coronary microcirculation disorders.Coronary microcirculation impairment is considered to be an independent risk factor determining the prognosis of coronary heart disease.The standardized mortality rate of coronary heart disease is still on the rise.How to improve the myocardial microcirculation disorder is a very important and urgent problem in the field of cardiovascular research.The author preliminarily understood the pathogenesis of myocardial microcirculation disorder from the pathophysiological point of view,briefly described the pathogenic characteristics and TCM mechanism of this disease from the perspective of traditional Chinese medicine,and looked for the breakthrough point of this disease.The pharmacological action of traditional Chinese medicine has the characteristics of multi-level,multi-target,multi-direction and multi-coverage,and has been widely used in the clinical treatment of myocardial microcirculation disorders.Based on the theory of“Qi deficiency and phlegm stasis”,this paper actively explores the etiology,pathogenesis and prevention and treatment rules of myocardial microcirculation disorders,which is of great significance to improve the research level of integrated Chinese and Western medicine prevention and treatment of this disease.

关 键 词：心肌微循环障碍 气虚痰瘀 冠心病 

分 类 号：R542.2[医药卫生—心血管疾病]