内养功联合滋阴清热安神汤对女性更年期失眠患者性激素及睡眠质量影响  

Effect of Intrinsic-nourishing Exercise Combined with Ziyin Qingre Anshen Decoction(滋阴清热安神汤)on Sex Hormones and Sleep Quality in Women with Menopausal Insomnia

作　　者：布立影 周婷婷 耿志月 焦妍 闫彤 BU Liying;ZHOU Tingting;CENG Zhiyue;JIAO Yan;YAN Tong(Hebei Medical Qigong Hospital,Qinhuangdao 066100,Hebei,China;North China University of Technology,Tangshan 063210,Hebei,China;Qinhuangdao Hospital of Traditional Chinese Medicine,Qinhuangdao 066000,Hebei,China)

机构地区：[1]河北省医疗气功医院,河北秦皇岛066100 [2]华北理工大学,河北唐山063210 [3]秦皇岛市中医院,河北秦皇岛066000

出　　处：《辽宁中医药大学学报》2022年第10期169-173,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(2022384)。

摘　　要：目的探讨内养功联合滋阴清热安神汤对女性更年期失眠患者性激素及睡眠质量影响。方法纳入河北省医疗气功医院符合诊断标准的女性更年期失眠人群88例,按照就诊先后顺序随机分为观察组与对照组,每组各44例,对照组口服艾司唑仑片及滋阴清热安神汤治疗,观察组在对照组基础上加用内养功锻炼,4周为1个疗程,共治疗2个疗程。观察治疗前后的临床疗效,匹兹堡睡眠质量指数(PSQI)评分,改良Kupperman量表评分,中医症状评分,多导睡眠呼吸监测(polysomnography,PSG)指标(入睡时间、总睡眠时间、睡眠效率),血清性激素[雌二醇(E_(2))、卵泡刺激素(FSH)、黄体生成素(LH)]水平,血清miR-155、miR-276a相对表达量。结果观察组治疗后总有效率(79.07%)高于对照组(59.09%)(P<0.05)。两组治疗后心烦不寐、月经周期紊乱、头晕耳鸣、腰膝酸软、五心烦热、口干汗出评分均较治疗前降低,且观察组低于对照组(P<0.05)。两组治疗后FSH、E_(2)水平较治疗前升高,且观察组高于对照组(P<0.05);两组治疗后LH水平与治疗前比较,差异无统计学意义(P>0.05)。两组治疗后PSQI评分、改良Kupperman量表评分均较治疗前降低,且观察组低于对照组(P<0.05)。两组治疗后入睡时间较治疗前降低,且观察组低于对照组(P<0.05);总睡眠时间、睡眠效率较治疗前升高,且观察组高于对照组(P<0.05)。两组治疗后血清miR-155、mi R-276a表达水平较治疗前升高,且观察组高于对照组(P<0.05)。结论内养功联合滋阴清热安神汤治疗女性更年期失眠患者疗效显著,可提高血清性激素水平,增加血清miR-155、miR-276a表达水平,改善睡眠质量。Objective To explore the effect of intrinsic-nourishing exercise combined with Ziyin Qingre Anshen Decoction(滋阴清热安神汤)on sex hormones and sleep quality in female patients with menopausal insomnia.Methods A total of 88 cases of female menopausal insomnia who met the diagnostic criteria in Hebei medical Qigong hospital were enrolled.They were randomly divided into observation group and control group according to the order of treatment,with 44 cases in each group.The control group was treated with estazolam tablets and Ziyin Qingre Anshen Decoction.In the observation group,the quality of intrinsic-nourishing exercise was added on the basis of the control group.4 weeks constituted a course of treatment,with a total of 2 courses of treatment.To observe the clinical efficacy before and after treatment,Pittsburgh Sleep Quality Index(PSQI)score,modified Kupperman scale score,TCM symptom score,polysomnography(PSG)indicators(sleep time,total sleep time,sleep efficiency),serum sex hormone levels[estradiol(E_(2)),follicle stimulating hormone(FSH),luteinizing hormone(LH)]changes,and the relative expression of mi R-155 and mi R-276 a in serum.Results After treatment,the total effective rate of the observation group(79.07%)was higher than that of the control group(59.09%)(P<0.05).After treatment,the scores of restlessness,insomnia,menstrual cycle disorder,dizziness and tinnitus,soreness and weakness of waist and knees,five heart upsets and heat,dry mouth and sweating in the two groups were all higher than those of the control group.Compared with before treatment,the observation group was lower than the control group(P<0.05).The levels of FSH and E_(2) in the two groups after treatment were higher than those before treatment,and the observation group was higher than the control group(P<0.05);and there was no significant difference of the LH level in the two groups after treatment(P>0.05).PSQI score and modified Kupperman scale score in the two groups after treatment were lower than those before treatment,and the obs

关 键 词：内养功 滋阴清热安神汤 女性更年期失眠 性激素 睡眠质量 

分 类 号：R256.23[医药卫生—中医内科学] R588.6[医药卫生—中医学]