多囊卵巢综合征患者血清GnSAF,Irisin,Copeptin表达水平及其与妊娠结局的相关性研究  

Changes of Serum GnSAF,Irisin and Copeptin Levels in Patients with Polycystic Ovary Syndrome and Their Relationship with Pregnancy Outcomes

作　　者：鲁霞 曹党恩 李晓兰[2] LU Xia;CAO Dang-en;LI Xiao-lan(Department of Obstetrics and Gynecology,the People’s Hospital of Daye City,Hubei Daye 435199,China;Department of Obstetrics and Gynecology,the Second People’s Hospital of Yichang City,the Second People’s Hospital of Three Gorges University,Hubei Yichang 443008,China)

机构地区：[1]湖北省大冶市人民医院妇产科,湖北大冶435199 [2]宜昌市第二人民医院,三峡大学第二人民医院妇产科,湖北宜昌443008

出　　处：《现代检验医学杂志》2022年第6期34-39,87,共7页Journal of Modern Laboratory Medicine

基　　金：湖北省卫健委联合基金面上项目(WJ2019H524)。

摘　　要：目的探讨多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者血清促性腺激素峰抑制因子(gonadotropin peak suppressor factor,GnSAF)、鸢尾素(Irisin)、和肽素(Copeptin)表达水平及其与妊娠结局的关系。方法将2018年10月~2020年10月湖北省大冶市人民医院诊治的PCOS患者106例设为PCOS组,另选择同期82例健康体检女性为对照组。收集两组有关临床资料,检测比较两组血清GnSAF,Irisin和Copeptin水平,分析PCOS患者血清GnSAF,Irisin,Copeptin水平与临床指标的相关性,应用Logistic回归分析探讨PCOS发生的影响因素,并对PCOS组行常规西医药物治疗,对比不同妊娠结局患者血清GnSAF,Irisin和Copeptin水平,应用受试者工作特征(ROC)曲线观察血清GnSAF,Irisin和Copeptin对患者妊娠结局的预测价值。结果PCOS组体质量指数(body mass index,BMI)25.28±3.76kg/m^(2)、空腹血糖(fasting blood glucose,FPG)5.47±0.58mmol/L,空腹胰岛素(fasting insulin,FINS)15.61±2.75mIU/L,稳态模型胰岛素抵抗指数(homeostasis model insulin resistance index,HOMA-IR)3.79±0.83,三酰甘油(triglyceride,TG)1.87±0.58mmol/L,睾酮(testosterone,T)1.94±0.53nmol/L,促黄体生成素(luteinizing hormone,LH)12.86±2.28mU/ml及血清GnSAF(22.00±1.93pg/ml),Irisin(3.09±0.69ng/L),Copeptin(12.61±3.27pmol/L)水平均高于对照组(22.06±3.27kg/m^(2),5.14±0.43mmol/L,9.04±2.49mIU/L,2.07±0.64,1.42±0.49mmol/L,1.21±0.34nmol/L,5.63±1.07mU/ml,19.82±2.26pg/ml,2.07±0.63ng/L,8.62±1.94pmol/L);高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)1.24±0.21mmol/L,雌二醇(estradiol,E2)112.48±19.55pmol/L水平均低于对照组(1.40±0.24mmol/L,134.06±24.16pmol/L),差异具有统计学意义(t=4.315~26.532,均P=0.000)。Pearson相关系数模型分析显示,血清GnSAF水平与E2呈负相关(r=-0.308),血清Irisin,Copeptin水平与BMI,FPG,FINS,HOMA-IR,TG水平呈正相关(r=0.321~0.649),与HDL-C水平呈负相关(r=-0.409),且血清Irisin水平与T水平呈正相关(r=0.321),差异均有�Objective To investigate the expression levels of serum gonadotropin peak suppressor factor(GnSAF),Irisin and Copeptinin patients with polycystic ovary syndrome(PCOS)and their relationship with pregnancy outcomes.Methods A total of 106 PCOS patients diagnosed and treated in the People’s Hospital of Daye City,Hubei Province from October 2018 to October 2020 were selected as the PCOS group,and 82 healthy women who underwent physical examination during the same period were selected as the control group.The relevant clinical data of the two groups were collected,and the serum levels of GnSAF,Irisin and Copeptin were detected and compared between the two groups.The correlation between serum GnSAF,Irisin and Copeptin levels and clinical indicators in PCOS patients was analyzed,and the influencing factors of PCOS were analyzed by logistic regression analysis.The PCOS group was treated with conventional western medicine,the serum levels of GnSAF,Irisin and Copeptin were compared in patients with different pregnancy outcomes,and the receiver operating characteristic(ROC)curve was used to observe the predictive value of serum GnSAF,Irisin and Copeptin on the pregnancy outcome of patients.Results PCOS group body mass index(BMI,25.28±3.76kg/m^(2)),fasting blood glucose(FPG,5.47±0.58mmol/L),fasting insulin(FINS,15.61±2.75mIU/L),homeostasis model insulin resistance index(HOMA-IR,3.79±0.83),triglyceride(TG,1.87±0.58mmol/L),testosterone(T,1.94±0.53nmol/L),luteinizing hormone(LH,12.86±2.28mU/ml)and serum GnSAF(22.00±1.93pg/ml),Irisin(3.09±0.69ng/L),Copeptin(12.61±3.27pmol/L)levels were higher than those in the control group(22.06±3.27kg/m^(2),5.14±0.43mmol/L,9.04±2.49mIU/L,2.07±0.64,1.42±0.49mmol/L,1.21±0.34nmol/L,5.63±1.07mU/ml,19.82±2.26pg/ml,2.07±0.63ng/L,8.62±1.94pmol/L),the levels of high-density lipoprotein cholesterol(HDL-C,1.24±0.21mmol/L)and estradiol(E2,112.48±19.55pmol/L)levels were lower than those of the control group(1.40±0.24mmol/L,134.06±24.16pmol/L),and the differences were statistically

关 键 词：多囊卵巢综合征 促性腺激素峰抑制因子 鸢尾素 和肽素 

分 类 号：R711.75[医药卫生—妇产科学] R392.11[医药卫生—临床医学]