输卵管妊娠患者血清IL-33和sST2表达水平与输卵管妊娠期待治疗疗效的相关性研究  

Correlation between the Expression Levels of Serum IL-33 and sST2 in Patients with Tubal Pregnancy and the Efficacy of Expectant Treatment for Tubal Pregnancy

作　　者：温小英[1] 乔印玲 邓桂林[1] WEN Xiao-ying;QIAO Yin-ling;DENG Gui-lin(Department of Gynecology,Guizhou Aerospace Hospital,Guizhou Zunyi 563000,China)

机构地区：[1]贵州航天医院妇科,贵州遵义563000

出　　处：《现代检验医学杂志》2022年第6期129-133,139,共6页Journal of Modern Laboratory Medicine

基　　金：遵市科合支撑HZ(2020)161号。

摘　　要：目的探讨白细胞介素(interleukin-33,IL)-33,可溶性ST2(soluble ST2,sST2)与输卵管妊娠期待治疗疗效关系及预测价值。方法选取2019年4月~2021年4月贵州航天医院137例输卵管妊娠患者,根据期待治疗是否成功分为成功组、未成功组。采用电化学发光法(electrochemiluminescence,ECL)检测治疗前、期待治疗7天后血清IL-33和sST2水平,应用放射免疫法(radioimmunoassay,RIA)检测治疗前、期待治疗7天后血清人绒毛膜促性腺激素(human chorionic gonadotropin,hCG)水平,分析IL-33,sST2与血清hCG相关性及期待治疗疗效的相关影响因素,并分析IL-33,sST2及联合预测期待治疗成功的价值,并比较不同IL-33,sST2表达水平患者期待治疗成功率。结果全组患者期待治疗中,92例(67.15%)患者成功,45例(32.85%)患者未成功;未成功组治疗前IL-33(110.97±36.05ng/ml)低于成功组(168.59±42.37ng/ml),sST2(31.52±5.83ng/ml)高于成功组(25.04±4.19ng/ml),差异具有统计学意义(t=7.837,7.442,均P<0.05);治疗后成功组IL-33(180.35±24.61ng/ml)高于治疗前(168.59±42.37ng/ml),sST2(19.52±5.27ng/ml)低于治疗前(25.04±4.19ng/ml),差异具有统计学意义(t=2.302,7.864,均P<0.05);治疗前、治疗后IL-33与hCG呈负相关(r=-0.867,-0.882,均P<0.001),治疗前、治疗后sST2与hCG呈正相关(r=0.815,0.849,均P<0.001);调整了临床表现、血清hCG两次检测变化、子宫内膜厚度混杂因素后,治疗前IL-33,sST2仍是发生期待治疗未成功的相关影响因素(均P<0.05);IL-33,sST2单一及两者联合预测输卵管妊娠的期待治疗成功的AUC分别为0.849,0703,0.911;IL-33高水平者成功率(91.89%)高于低水平者(38.10%),sST2高水平者成功率(55.79%)低于低水平者(92.86%),差异均有统计学意义(χ^(2)=44.648,18.142,均P<0.05)。结论IL-33,sST2均与输卵管妊娠期待治疗成功情况有关。两者联合检测可作为预测期待治疗疗效的生物标志物,指导临床治疗决策。Objective To explore the value of interleukin-33(IL-33)and soluble ST2(sST2)in predicting the success of expectant treatment of tubal pregnancy.Methods 137 patients with tubal pregnancy in Guizhou Aerospace Hospital from April 2019 to April 2021 were selected and divided into successful group and unsuccessful group according to whether they expected treatment to be successful or not.Serum IL-33,sST2 levels before treatment and after 7d of expectant treatment were detected by electrochemiluminescence(ECL),and serum human chorionic gonadotropin(hCG)levels before treatment and after 7 d of expectant treatment were detected by radioimmunoassay(RIA).The correlation between IL-33,sST2 and serum hCG,and the efficacy of expectant treatment were analyzed.The value of IL-33,sST2 and the combination to predict the success of prospective treatment were analyzed,and compared the success rate of prospective treatment in patients with different IL-33,sST2 expression levels.Results The whole group of patients were expecting treatment,92 patients(67.15%)were successful and 45 patients(32.85%)were unsuccessful.IL-33(110.97±36.05ng/ml)before treatment in the unsuccessful group was lower than that in the successful group(168.59±42.37ng/ml)and sST2(31.52±5.83ng/ml)was higher than that in the successful group(25.04±4.19ng/ml),the differences were statistically significant(t=7.837,7.442,all P<0.05).IL-33(180.35±24.61ng/ml)was higher in the success group than before treatment(168.59±42.37ng/ml),and sST2(19.52±5.27ng/ml)was lower than before treatment(25.04±4.19ng/ml),the differences were statistically significant(t=2.302,7.864,all P<0.05).IL-33 was negatively correlated with hCG before and after treatment(r=-0.867,-0.882,all P<0.001),and sST2 was positively correlated with hCG before and after treatment(r=0.815,0.849,all P<0.001).After adjusting for clinical manifestations,changes in serum hCG twice tested,and endometrial thickness confounders,IL-33 and sST2 before treatment were still relevant influences for the occurrence of u

关 键 词：白细胞介素-33 可溶性ST2 输卵管妊娠 期待治疗 

分 类 号：R714.221[医药卫生—妇产科学] R392.11[医药卫生—临床医学]