乙肝病毒载量对妊娠期糖尿病的影响研究  

The influence of hepatitis B viral load on gestational diabetes mellitus

作　　者：梁琼文 周正银 韦丽 黄元娇 Liang Qiongwen;Zhou Zhengyin;Wei Li;Huang Yuanjiao(Department of Obstetrics,Guidong People's Hospital of Guangxi Zhuang Autonomous Region,Wuzhou 543000,China)

机构地区：[1]广西壮族自治区桂东人民医院产科,广西梧州543000

出　　处：《实用妇科内分泌电子杂志》2022年第14期1-3,共3页Electronic Journal of Practical Gynecological Endocrinology

基　　金：贺州市科学研究与技术开发计划项目(编号:贺科技20065)。

摘　　要：目的探讨乙型肝炎病毒(HBV)载量高低对妊娠期糖尿病(GDM)发病情况的影响。方法随机选择孕妇411例为研究对象。以乙肝表面抗原阴性者为A组(对照组),共317例;以乙肝表面抗原阳性,肝功能正常者为B组,共68例,按照HBV-DNA的载量不同分为:①B1组(HBV-DNA定量<2×10^(5)IU/ml),共42例;②B2组(HBV-DNA定量≥2×10^(5)IU/ml),共26例;以乙肝表面抗原阳性,肝功能异常者为C组,共26例,再按照HBV-DNA的载量不同分为:①C1组(HBV-DNA定量<2×10^(5)IU/ml),共8例;②C2组(HBV-DNA定量≥2×10^(5)IU/ml),共18例。比较五组孕妇GDM发生情况。结果五组孕产妇GDM发病率比较结果显示,C组GDM发病率为34.62%,C2组GDM发病率为38.89%,均高于A组的17.67%,差异均有统计学意义(P<0.05);而A组与B组、B1组、B2组、C1组,B组与C组,B1组与B2组,C1组与C2组患者GDM发生率比较,差异均无统计学意义(P>0.05)。结论HBV载量高低在临床中对于GDM的发病率影响不大,乙肝表面抗原阳性合并肝功能异常者更容易发生GDM。Objective To investigate the effect of hepatitis B virus(HBV)load on the incidence of gestational diabetes mellitus(GDM).Methods A total of 411 pregnant women were randomly selected as subjects.Group A(control group)consisted of 317 cases with negative HBSAG.A total of 68 patients with HBSAG positive and normal liver function were divided into group B,and in group B,they were divided according to the load of HBV-DNA:there were 42 patients in group B1(HBV-DNA quantification<2×10^(5)IU/ml),and 26 patients in group B2(HBV-DNA quantification≥2×10^(5)IU/ml).According to the load of HBV-DNA,26 cases were divided into group C:8 cases were divided into group C1(HBV-DNA quantification<2×10^(5)IU/ml);there were 18 cases in C2 group(HBV-DNA quantification≥2×10^(5)IU/ml).The incidence of GDM was compared among the five groups.Results Comparison of the incidence of GDM among five groups of pregnant women showed that,the incidence of GDM in group C was 34.62%,and that in group C2 was 38.89%,both higher than that in group A(17.67%),and the diferences were statistically significant(P<0.05).There was no significant difference in the incidence of GDM between group A and group B,group B1,group B2,group C1,group B and group C,group B1 and group B2,and group C1 and group C2(P>0.05).Conclusion HBV load has little effect on the incidence of GDM in clinic.Patients with HBSAG positive and abnormal liver function are more likely to develop GDM.

关 键 词：乙型肝炎病毒 妊娠期糖尿病 孕妇血糖 

分 类 号：R714.256[医药卫生—妇产科学]