甘精/速效胰岛素治疗对危重症合并糖尿病患者低血糖发生率及血糖达标时间的影响对比  

Comparison of the Effect of Glargine/rapid-acting Insulin Therapy on the In⁃cidence of Hypoglycemia and the Time to Reach Blood Glucose in Critically Ill Patients with Diabetes Mellitus

作　　者：姚晖 范华贵 冯俊 YAO Hui;FAN Huagui;FENG Jun(Department of Critical Care Medicine,Nanping First Hospital Affiliated to Fujian Medical University,Nanping,Fujian Province,353006 China)

机构地区：[1]福建医科大学附属南平第一医院重症医学科,福建南平353006

出　　处：《糖尿病新世界》2022年第19期74-77,共4页Diabetes New World Magazine

摘　　要：目的 对比甘精胰岛素、速效胰岛素治疗对危重症合并糖尿病患者低血糖发生率及血糖达标时间的影响。方法 选取2021年1月—2022年1月福建医科大学附属南平第一医院收治的80例危重症合并糖尿病患者作为研究对象,随机纳入观察组(n=40)和对照组(n=40)。对照组患者采用速效胰岛素治疗,观察组患者采用甘精胰岛素治疗。比较两组患者低血糖发生情况及血糖达标时间。结果 观察组入住ICU期间Glu CV、Glu SD、Glu Max、Glu Ave水平均显著低于对照组,差异有统计学意义(P<0.05)。相比于对照组,观察组的胰岛素用量明显减少,治疗后血糖水平明显降低,血糖达标时间明显缩短,差异有统计学意义(P<0.05)。相比于对照组,观察组的低血糖发生率明显减少,差异有统计学意义(P<0.05)。结论 在对危重症合并糖尿病患者进行治疗时,相比于速效胰岛素治疗,采用甘精胰岛素治疗能使血糖水平快速达标,明显减少血糖波动及低血糖发生率。Objective To compare and analyze the effects of insulin glargine and rapid-acting insulin on the incidence of hypoglycemia and the time to reach the blood glucose target in critically ill patients with diabetes mellitus.Methods A total of 80 critically ill patients with diabetes mellitus admitted to Nanping First Hospital Affiliated to Fujian Medical University from January 2021 to January 2022 were selected as the research subjects.They were randomly divided into observation group(n=40)and control group(n=40).The patients in the control group were treated with fast-acting insulin,and the patients in the observation group were treated with insulin glargine.The incidence of hypoglycemia and the time to reach the blood glucose standard were compared between the two groups.Results The levels of Glu CV,Glu SD,Glu Max,and Glu Ave in the observation group during ICU stay were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).Compared with the control group,the insulin dosage of the observation group was significantly decreased,after treatment,the blood glucose level was significantly decreased,the time to reach the blood glucose standard was significantly shortened,and the difference was statistically significant(P<0.05).Compared with the control group,the hypoglycemia in the observation group was significantly reduced,and the difference was statistically significant(P<0.05).Conclusion In the treatment of critically ill patients with diabetes mellitus,compared with rapid-acting insulin therapy,insulin glargine therapy can quickly reach the blood glucose level,and significantly reduce blood glucose fluctuations and hypoglycemia.

关 键 词：甘精胰岛素 短效胰岛素 危重症 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]