A canine model of aortic arch aneurysm created with autologous pericardium  

作　　者：Weixiao Li Jun Li Qiang li Mingzhe Cui Rutao Xu Shuiting Zhai Cheshire Nick Tianxiao Li Jiangbo Chen Wenli Zhao 

机构地区：[1]Department of Vascular and Endovascular Surgery,Zhengzhou University People's Hospital,Henan Provincial Peoples Hospital,Zhenghou,China [2]Operation Department,Zhengzhou University People's Hospital,Henan Provincial People's Hospital,Zhenghou,China [3]Department of Medical Imaging,Zhengzhou University People's Hospital,Henan Provincial People's Hospital,Zhenghou,China [4]Department of Vascular Surgery,Royal Brompton and Harefield Hospital,London,UK [5]Department of Cerebrovascular Disease,Zhengzhou University People's Hospital,Henan Provincial People's Hospital,Zhenghou,China

出　　处：《Journal of Interventional Medicine》2022年第3期133-137,共5页介入医学杂志（英文）

基　　金：supported by the Henan medical science and technology research projects(222102310014 and LGHJ20200058)。

摘　　要：Background:To establish a canine model of aortic arch aneurysm that is suitable for research on new devices and techniques applied to the aortic arch.Materials and methods:Fifteen mongrel dogs underwent surgery.The autologous pericardial patch was sewn on the aortotomy site in the anterior wall of the aortic arch.The animals were followed up for 3 months postoperatively.Computed tomography angiography was used to visualize and measure the aneurysm model.Hematoxylin and eosin staining was used to observe the histological characteristics of the aneurysm model.Changes in aneurysm diameter over time were analyzed using analysis of variance.Results:One dog died of hemorrhage during surgery.Fourteen dogs survived the surgical procedure.Two of them died on the first postoperative day because of ruptures at the suturing margin.The diameter of the aneurysm model was twice as large as that of the aortic arch.There was no significant change in the maximum diameter of the aneurysm model during the follow-up period.Conclusions:We established a controllable and stable aortic arch aneurysm model created with an autologous pericardium patch.The aneurysm model can be used to research endoleaks after thoracic endovascular aortic repair and new endovascular techniques can be applied to the aortic arch.

关 键 词：Aortic aneurysm Pericardium patch Ascending aorta Aortic arch Animal model 

分 类 号：R654.3[医药卫生—外科学] R-332[医药卫生—临床医学]