子痫前期患者血清PP13、FABP-4的表达及其与不良妊娠结局的关系  

Expression of serum PP13 and FABP-4 in patients with preeclampsia and their relationship with adverse pregnancy outcomes

作　　者：李燕婷[1] 郝曼 王晓霞[3] 许晓英[1] LI Yanting;HAO Man;WANG Xiaoxia;XU Xiaoying(Perinatal Medical Center,Gansu Provincial Maternity and Child-care Hospital,Lanzhou,Gansu 730050,China;Fetal Medicine Department,Gansu Provincial Maternity and Child-care Hospital,Lanzhou,Gansu 730050,China;Reproductive Endocrinology Department,Gansu Provincial Maternity and Child-care Hospital,Lanzhou,Gansu 730050,China)

机构地区：[1]甘肃省妇幼保健院围产医学中心,甘肃兰州730050 [2]甘肃省妇幼保健院胎儿医学科,甘肃兰州730050 [3]甘肃省妇幼保健院生殖内分泌科,甘肃兰州730050

出　　处：《中国优生与遗传杂志》2022年第9期1613-1618,共6页Chinese Journal of Birth Health & Heredity

基　　金：甘肃省卫生行业科研计划管理项目(GSWSKY2018-30)。

摘　　要：目的探讨血清胎盘蛋白13(PP13)、脂肪酸结合蛋白(FABP)-4在子痫前期(PE)患者中的表达,并分析血清PP13、FABP-4与PE患者不良妊娠结局的关系。方法选取甘肃省妇幼保健院2018年1月至2021年12月收治的107例PE患者作为观察组,同期选取医院接受孕检的107例正常妊娠孕妇作为对照组,均于入院当天检测血清PP13、FABP-4等实验室指标。全部PE患者均接受相应治疗,并记录患者妊娠结局。由研究人员自制基线资料调查表,调查、记录患者基线资料,重点分析血清PP13、FABP-4在PE患者中的表达,及其与患者不良妊娠结局的关系。结果观察组血清PP13水平低于对照组,FABP-4水平高于对照组,差异有统计学意义(P<0.05);107例PE患者中,有20例患者发生不良妊娠结局,发生率为18.69%;不良组血清PP13水平低于良好组,FABP-4水平和24 h尿蛋白定量高于良好组,差异有统计学意义(P<0.05);经Logistic回归分析结果显示,24h尿蛋白定量、血清PP13和FABP-4水平与PE患者不良妊娠结局有关(P<0.05);绘制受试者操作特征(ROC)曲线显示,单独及联合预测PE患者不良妊娠结局的曲线下面积(AUC)均>0.70,均有一定的预测价值,且以联合预测的价值最好;限制性立方样条分析结果显示,血清PP13、FABP-4与PE患者不良妊娠结局呈线性剂量反应关系(P<0.05)。结论PE患者血清PP13水平明显降低,血清FABP-4水平明显升高,且与患者不良妊娠结局存在一定的关系。Objective To investigate the expression of serum placental protein 13(PP13)and fatty acid binding protein(FABP)-4 in patients with preeclampsia(PE),and to analyze the relationship between serum PP13,FABP-4 and adverse pregnancy outcomes in patients with PE.Methods 107 patients with PE treated in Gansu Provincial Maternity and Child-care Hospital from January 2018 to December 2021 were selected as the observation group,and 107 normal pregnant women who underwent pregnancy examination in the hospital during the same period were selected as the control group.Serum PP13,FABP-4 and other laboratory indexes were detected on the day of admission.All patients with PE received corresponding treatment,and the pregnancy outcome was recorded.The researchers made a baseline data questionnaire to investigate and record the baseline data of patients.The expression of serum PP13 and FABP-4 in patients with PE and their relationship with adverse pregnancy outcomes were mainly analyzed.Results The level of serum PP13 in the observation group was lower than that in the control group,and the level of FABP-4 was higher than that in the control group,with statistical significant differences(P<0.05),among 107 patients with PE,20 patients had adverse pregnancy outcomes,and the incidence rate was 18.69%.Compared with the good group,the level of serum PP13 in the adverse group was lower,and the level of FABP-4 and 24 h urinary protein were higher,with statistical significant differences(P<0.05).The results of Logistic regression analysis showed that,24 h urinary protein,serum PP13 and FABP-4 levels were related to adverse pregnancy outcomes in patients with PE(P<0.05).The receiver operating characteristic(ROC)curve showed that the area under the curve(AUC)for predicting the adverse pregnancy outcome of PE patients alone and in combination were>0.70,both had certain prediction value,and the value of joint prediction was the best.By restricted cubic spline analysis,the results showed that,there was a linear dose-response relationship betwee

关 键 词：子痫前期 妊娠结局 胎盘蛋白13 脂肪酸结合蛋白-4 

分 类 号：R714.244[医药卫生—妇产科学]