邯郸地区1160对胚胎停育夫妇的异常染色体研究  

Study on abnormal chromosome of 1160 couples with embryo damage in Handan district

作　　者：平慧[1] 李守霞[1] 郭红霞[1] 郝润英[1] 郭丽丽[1] 宋亚娟[1] 鲁静 PING Hui;LI Shouxia;GUO Hongxia;HAO Runying;GUO Lili;SONG Yajuan;LU Jing(Clinical Laboratory of Handan Central Hospital,Handan,Hebei 056001,China)

机构地区：[1]邯郸市中心医院检验科,河北邯郸056001

出　　处：《中国优生与遗传杂志》2022年第9期1668-1670,共3页Chinese Journal of Birth Health & Heredity

基　　金：邯郸市科学技术研究与发展计划项目(21422083113)。

摘　　要：目的 研究夫妇双方异常染色体与胚胎停育间的联系。方法 对本地区1160对胚胎停育夫妇的染色体探索研究。结果 检出187例染色体异常核型,检出率8.06%,包括36例结构异常,占19.25%;3例数目异常,占1.60%;4例倒位,占2.14%;144例染色体多态性,占77.01%。其中男性染色体异常检出率(62.57%)明显高于女性(37.43%)。结论 染色体异常是胚胎停育不可忽视的因素之一,对胚胎停育夫妇应重视其染色体检查,以便提供孕前遗传咨询和指导。Objective To study the connection between chromosomal abnormality and couples with embryo damage.Methods Chromosome exploration and study of 1160 couples with embryo damage in this district. Results 187 cases of chromosomal abnormality were detected, the detection rate was 8.06%, among which 36 cases(19.25%) were structural abnormality, 3 cases(1.60%) were numerical abnormality. 4 cases(2.14%) were inverted. 144 cases(77.01%) were chromosomal polymorphism. The detection rate of of men(62.57%) was obviously higher than that of women(37.43%). Conclusion Chromosomal abnormality is one of the factors that can not be ignored in couples with embryo damage. Chromosome examination should be paid more attention to couples with embryo damage, so as to provide genetic counseling and guidance.

关 键 词：胚胎停育 异常核型 遗传咨询 

分 类 号：R714.2[医药卫生—妇产科学]