Sticking-bacteria gel enhancing anti-multidrug-resistant microbial therapy under ultrasound  

作　　者：Ya-Qi Zhu Wei-Qiang Huang Guang Chen Lei Xia Ye-Zi You Yue Yu 

机构地区：[1]The Department of Gastroenterology,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230026,China [2]Department of Polymer Science and Engineering,University of Science and Technology of China,Hefei 230026,China

出　　处：《Nano Research》2022年第10期9105-9113,共9页纳米研究（英文版）

基　　金：supported by the National Key Research and Development Program of China(No.2020YFA0710700);the National Natural Science Funds for Distinguished Young Scholars(No.51625305);the National Natural Science Foundation of China(Nos.52131305,52073269,51873202,22131010,22101275,81603339,81602344,and 31870993);the Fundamental Research Funds for the Central Universities(Nos.YD2060002016 and WK9110000005).

摘　　要：The use of antibiotic could cause severe drug-resistance and the increasing spread of pathogenic drug-resistant bacteria has brought a big threat to human health,hence,some innovative methods inspired,such as sonodynamic therapy,have become increasingly attractive for realizing the antibiotic-free methods against bacterial infection.However,many pathogens can invade normal healthy cells to establish intracellular replicative niches,which makes it more difficult to kill and remove these bacteria.Herein,inspired by respiratory mucus trapping bacteria to kill them,we developed a novel gel of amorphous TiO_(x) nanofibers dotted with Ti_(2)C(OH)_(2) nanosheets,which could capture and trap bacteria into the gel via a strong binding ability toward bacteria by forming a Ti–O–P bond between phosphate in the bacterial wall and Ti-OH in the gel,thereby,efficiently blocking the invasions of bacteria.Also,the gel has excellent ability for generating reactive oxygen species(ROS)under ultrasound irradiation,therefore,the bacteria in the gel could be effectively killed by the ROS produced under ultrasound irradiation.Moreover,Ti2C(OH)2 in the gel was able to scavenge H_(2)O_(2),and transfer it into O_(2) in the infection environment,providing enough O_(2) for sonodynamic therapy.The experimental results have demonstrated that the functional gel obviously accelerated the healing of multidrug-resistant microorganisms-infected wounds.

关 键 词：multidrug-resistant bacteria GEL ULTRASOUND bacteria-sticking 

分 类 号：R45[医药卫生—治疗学]