Green functional carbon dots derived from herbal medicine ameliorate blood–brain barrier permeability following traumatic brain injury  

作　　者：Weikang Luo Lianglin Zhang Xuexuan Li Jun Zheng Quan Chen Zhaoyu Yang Menghan Cheng Yao Chen Yao Wu Wei Zhang Tao Tang Yang Wang 

机构地区：[1]Institute of Integrative Medicine,Department of Integrated Traditional Chinese and Western Medicine,Xiangya Hospital,Central South University,Changsha 410008,China [2]Laboratory for interdisciplinary science of traditional Chinese medicine,Xiangya Hospital,Central South University,Changsha 410008,China [3]National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha 410008,China [4]College of Chemistry and Chemical Engineering,Central South University,Changsha 410083,China [5]The College of Integrated Traditional Chinese and Western Medicine,Hunan University of Chinese Medicine,Changsha 410208,China

出　　处：《Nano Research》2022年第10期9274-9285,共12页纳米研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.81973665);the Science and Technology Innovation Program of Hunan Province(No.2021RC3030);the Fundamental Research Funds for the Central Universities of Central South University(No.2021zzts1028);the InnovationDriven Project of Central South University(No.2020CX047).

摘　　要：To repair the blood–brain barrier(BBB)after traumatic brain injury(TBI)remains a multidisciplinary challenge.No first-line drugs are available.Here,we reported a novel and non-toxic functional negative-charged carbon dots(CDs)generated from green Semen pruni persicae and Carthamus tinctorius L.(TH-CDs)through a hydrothermal synthesis without any organic solvent.The surface of TH-CDs retained part functional groups of active pharmacophores from both drugs.TH-CDs could improve the neurological function,brain edema,neuronal damage,and the BBB permeability by tail vein injection of mice models without systemic toxicity.Furthermore,higher expression of tight junction proteins claudin 5 and ZO-1 was observed after TH-CDs administration,which may be due to the electrostatic interaction between TH-CDs and claudin 5.Our study highlights an inexpensive,green,non-toxic,and intravenous functional TH-CD,which represents a potential TBI treatment strategy.

关 键 词：carbon dots traumatic brain injury herbal medicine blood-brain barrier claudin 5 

分 类 号：R651.15[医药卫生—外科学]