Pharmacological monitoring and literature analysis of dagliflozin in patients with hypovolemia  

达格列净在血容量不足患者中的药学监护及文献分析

作　　者：Ye Yuan Bo Yu Zhenzhen Yang Weichong Dong Xiuling Yang 袁叶;于博;杨珍珍;董维冲;杨秀岭(河北医科大学第二医院,河北石家庄050000)

机构地区：[1]The Second Hospital of Hebei Medical University,Shijiazhuang 050000,China

出　　处：《Journal of Chinese Pharmaceutical Sciences》2022年第9期718-722,共5页中国药学（英文版）

摘　　要：In the present study,we aimed to explore the timing of dosing with dapagliflozin(DAPA)in patients with hypovolemia and the role of the clinical pharmacist in pharmacological monitoring.The clinical pharmacist was involved in the dosing regimen of two patients with hypovolemia using DAPA and advising patients with insufficient blood volume to withhold the use of the drug.They reviewed the relevant literature to provide a theoretical basis for clinicians and the role of clinical pharmacists in pharmacy services.When considering patients with hypovolemia,the clinical pharmacist can promptly identify that DAPA can reduce blood volume and provide rational advice and rationale for the patient‟s medication that is adopted by the clinician,resulting in an individualized dosing regimen for the patient.Clinical pharmacists are advised to pay attention to the dosing adjustments of DAPA when patients are in hypovolemia and to be more alert to the adverse effects that can result from its use.本文探讨临床血容量不足的患者在使用达格列净降低血糖及改善心衰时的用药时机及临床药师在药学监护中的作用。临床药师参与两例血容量不足患者使用达格列净的用药方案,建议血容量不足患者暂停使用该药物,并查阅相关文献,为临床医生提供理论依据,发挥临床药师在药学服务中的作用。考虑患者出现血容量不足时,临床药师能及时发现达格列净可降低血容量,为患者用药提出合理建议及理论依据并被临床医生所采纳,为患者制定个体化给药方案。本文提示临床药师在患者处于血容量不足时,应重视达格列净的用药调整,提高用药可导致不良影响的警惕性。

关 键 词：Dagliflozin HYPOVOLEMIA Pharmacological monitoring Literature analysis Clinical pharmacist 

分 类 号：R977.15[医药卫生—药品]