凝血因子Ⅷ活性检测现状及发展趋势  

Current status and development trend of coagulation factorⅧactivity

作　　者：刘禹 许冠群[1] 戴菁[1] 王学锋[1] Liu Yu;Xu Guanqun;Dai Jing;Wang Xuefeng(Department of Laboratory Medicine,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院检验科,上海200025

出　　处：《中华检验医学杂志》2022年第10期1010-1016,共7页Chinese Journal of Laboratory Medicine

基　　金：国家自然科学基金(81770131)。

摘　　要：凝血因子Ⅷ(FⅧ)活性检测在血友病A、获得性血友病A及血管性血友病的诊断、分型、疗效监测和抑制物滴度检测等各方面中起着至关重要的作用。然而由于检测系统多样化、试剂组分的差异及干扰物质的存在等影响因素,国内实验室的FⅧ活性检测仍有改进空间。The detection of coagulation factor Ⅷ activity plays an important role in the diagnosis, typing, efficacy monitoring and detection of inhibitor titer in hemophilia A, acquired hemophilia A and von Willebrand disease. However, due to the diversity of detecting systems, the difference of reagent composition, the existence of interfering substances and other influence factors, the detection of coagulation factor Ⅷ activity in the laboratories in China still needs to be improved.

关 键 词：因子Ⅷ 凝血因子Ⅷ活性 一期法 发色底物法 影响因素 

分 类 号：R446.1[医药卫生—诊断学]