Cross-coupling of 2-methylquinolines and in-situ activated isoquinolines:Construction of 1,2-disubstituted isoquinolinones  

作　　者：Jianyi Shi Zheng Zeng Shengting Xu Zechun Cai Yuehua Luo Yongbo Fan Zhongzhi Zhu Tingting Wen Xiuwen Chen 

机构地区：[1]School of Biotechnology and Health Sciences,Wuyi University,Jiangmen 529020,China [2]Affiliated Hospital of Guilin Medical University,Guilin 541001,China

出　　处：《Chinese Chemical Letters》2022年第11期4874-4877,共4页中国化学快报（英文版）

基　　金：Foundation of the National Natural Science Foundation of China(No.22101212);“Climbing Program”(No.pdjh2021a0505)Special Funds;Science Foundation for Young Teachers of Wuyi University(No.2019td06);Guangdong Basic and Applied Basic Research Foundation(Nos.2019A1515110866,2019A1515110522);College Students Innovation and Entrepreneurship Training Program of Wuyi University(Nos.202111349020,202111349308S)for financial support。

摘　　要：In this study,a method was developed to form C(sp^(3))-C(sp^(2))bonds via copper catalyst-promoted cross coupling of 2-methylquinoline and in-situ-activated 3-haloisoquinoline under mild conditions.The multi-component tandem reaction was used to construct new C-N,C=O and C-C bonds in one pot via sequential functionalization of the N1,C3 and C1 positions of 3-haloisoquinoline.This method can be used to efficiently access 1,2-disubstituted isoquinolinones by the three-component reaction of 3-halogen isoquinoline,alkyl halide,and 2-methylquinoline.

关 键 词：Isoquinolinones In-situ activated Three-component reaction One-pot Trifunctionalisation 

分 类 号：O626.323[理学—有机化学]