MUC1 vaccines usingβ-cyclodextrin grafted chitosan(CS-g-CD)as carrier via host-guest interaction elicit robust immune responses  

作　　者：Hangyan Yu Han Lin Yuntian Xie Mengyuan Qu Min Jiang Jie Shi Haofei Hong Hongrui Xu Ling Li Guochao Liao Zhimeng Wu Zhifang Zhou 

机构地区：[1]The Key Laboratory of Carbohydrate Chemistry&Biotechnology,Ministry of Education,School of Biotechnology,Jiangnan University,Wuxi 214122,China [2]Suzhou Municipal Center for Disease Control and Prevention,Suzhou 215004,China [3]Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China,International Institute for Translational Chinese Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006,China

出　　处：《Chinese Chemical Letters》2022年第11期4882-4885,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.21907038 and 32000904);Natural Science Foundation of Jiangsu Province(No.BK20200601);National Postdoctoral Program for Innovative Talents of China(No.BX20200153);China Postdoctoral Science Foundation(Nos.2018M632227 and2021M691293);the Social Development Key Project of Jiangsu Province(No.BE2019632);the Health and Family Planning Commission of Wuxi,China(No.Z202005);Suzhou People’s Livelihood Science and Technology Project,China(No.SYS2018100);supported by the 111 Project(No.111-2-06)。

摘　　要：We construct MUC1 vaccines usingβ-cyclodextrin grafted chitosan(CS-g-CD)as carrier via host-guest interaction.These vaccines based on non-covalent assembling can provoke robust immune responses,including high level of specific antibodies and cytokines.The induced antibodies can specifically recognize tumor cells and mediate cytotoxicity against tumor cells.These results indicate that CS-g-CD with strong immunostimulatory activities can be a straightforward platform for peptide-based vaccine construction.

关 键 词：β-Cyclodextrin grafted chitosan MUC1 antigen Cancer vaccine Host-guest interaction Vaccine carrier Tn antigen 

分 类 号：TQ464[化学工程—制药化工]