Metal coordination to a deep cavitand promotes binding selectivities in water  

作　　者：Yong-Qing Chen Hua-Wei Guan Kuppusamy Kanagaraj Julius Rebek Yang Yu 

机构地区：[1]Center for Supramolecular Chemistry and Catalysis and Department of Chemistry,College of Science,Shanghai University,Shanghai 200444,China [2]Skaggs Institute for Chemical Biology and Department of Chemistry,The Scripps Research Institute,La Jolla,CA 92037,United States

出　　处：《Chinese Chemical Letters》2022年第11期4908-4911,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.22071144 and 21801164);Shanghai University(No.13-G210-20-201);the Program for Professor of Special Appointment(Dongfang Scholarship)of the Shanghai Education Committee。

摘　　要：One goal of supramolecular chemistry is the creation of synthetic receptors that have a high affinity for hydrophilic molecules in water.We found that cavitands with upper rims extended by pyridyl groups coax hydrophilic guests into the cavity where they are shielded from the aqueous environment.The ability of Pd(Ⅱ)to coordinate adjacent pyridyl groups leads to increased selectivity for highly hydrophilic solvent molecules such as acetone,1,4-dioxane and tetrahydrofuran in water.Analysis of the binding behavior indicated that metal-coordination restricts the container entrance,shrinks the effective cavity volume and increases the energetic barrier to guest exchange.

关 键 词：Host-guest chemistry Metallo cavitand Hydrophilic small molecules Molecular recognition Water-soluble containers 

分 类 号：O641.4[理学—物理化学]