Insight into the in vivo fate of intravenous herpetrione amorphous nanosuspensions by aggregation-caused quenching probes  

作　　者：Lingyu Hang Chengying Shen Baode Shen Hailong Yuan 

机构地区：[1]Department of Pharmacy,Air Force Medical Center,PLA,Beijing 100142,China [2]College of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang 330004,China [3]Department of Pharmacy,Jiangxi Provincial People's Hospital,Nanchang 330006,China

出　　处：《Chinese Chemical Letters》2022年第11期4948-4951,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.81873092,81573697,82174074,81803741)。

摘　　要：Intravenous nanosuspensions are attracted growing attention as a viable strategy for development of intravenous formulations of poorly water-soluble drugs.However,only few information about the biological fate of intravenous nanosuspensions is currently known,especially amorphous nanosuspensions are not reported yet.In this study,the in vivo fate of herpetrione(HPE)amorphous nanosuspensions following intravenous administration was explored by using an aggregation-caused quenching(ACQ)probe and HPLC methods.The ACQ probe is physically embedded into HPE nanoparticles via anti-solvent method to form HPE hybrid nanosuspensions(HPE-HNSs)for bioimaging.HPE-HNSs emit strong and stable fluorescence,but fluorescence quenches immediately upon the dissolution of HPE-HNSs,confirming the selfdiscrimination of HPE-HNSs.Following intravenous administration of HPE-HNSs,integral HPE-HNSs and HPE show similar degradation and biodistribution,with rapid clearance from blood circulation and obvious accumulation in liver and lung.Due to the slower dissolution and enhanced recognition by reticuloendothelial system,450 nm HPE-HNSs accumulate more in liver,lung and spleen than that of 200 nm HPE-HNSs.These results demonstrate that integral HPE-HNSs determine the in vivo performance of HPEHNSs.This study provides insight into the in vivo fate of intravenous amorphous nanosuspensions.

关 键 词：Amorphous nanosuspensions Herpetrione In vivo fate Intravenous delivery Aggregation-caused quenching 

分 类 号：TQ460.1[化学工程—制药化工] TB383.1[一般工业技术—材料科学与工程]