IDEAL-IQ技术定量评估中老年志愿者大腿肌肉脂肪含量及其与肌力相关性的初步研究  

A preliminary study on quantitative evaluation of thigh muscle fat content with IDEAL-IQ technique and correlation with muscle strength in the middle-aged and elderly volunteers

作　　者：朱红丽 黄益龙[1] 严俊 王玲[3] 程晓光[3] 寸晗雪 丁桃[4] 王昊雷 高超[1] 何波[1] Zhu Hongli;Huang Yilong;Yan Jun;Wang Ling;Cheng Xiaoguang;Cun Hanxue;Ding Tao;Wang Haolei;Gao Chao;He Bo(Department of Medical Imaging,First Affiliated Hospital of Kunming Medical University,Kunming 650032,China;Department of Radiology,the First People′s Hospital of Qujing City,Qujing 655099,China;Department of Radiology,Beijing Jishuitan Hospital,Beijing 100035,China;Department of Rehabilitation,First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院医学影像科,昆明650032 [2]曲靖市第一人民医院放射科,曲靖655099 [3]北京积水潭医院放射科,北京100035 [4]昆明医科大学第一附属医院康复科,昆明650032

出　　处：《中华放射学杂志》2022年第10期1129-1134,共6页Chinese Journal of Radiology

基　　金：云南省校联合科研项目(202001AY070001-038);云南省骨关节疾病、放射与治疗临床医学中心项目(ZX2019-03-04,202102AA100067);云南省教育厅科学研究基金(2019J1245)。

摘　　要：目的探讨采用最小二乘法估计和不对称回波迭代分解水和脂肪成像(IDEAL-IQ)技术定量评估中老年志愿者大腿肌肉脂肪含量的价值及其与肌力的相关性。方法2020年12月至2021年4月间,前瞻性招募30名年龄为45~70岁的志愿者,男15名、女15名,年龄52.5(49.0,56.3)岁。所有受试者均接受MR扫描,包括左侧大腿中段横断面T1WI、IDEAL-IQ序列和冠状面T2WI,勾画左侧大腿中段伸肌群(股四头肌)及屈肌群(腘绳肌)感兴趣区,获得肌肉横截面积(CSA)、骨骼肌指数(SMI)、肌间脂肪分数(FF)和肌内FF。此外,选取60°/s、180°/s的角速度对所有受试者左膝关节进行等速肌力测试,获得膝关节屈、伸肌群的峰力矩(PT)及总功(TW)。采用独立样本t检验、配对t检验或Mann-Whitney U检验比较不同性别、肌群间CSA、SMI、肌间FF、肌内FF、PT、TW的差异。采用Pearson或Spearman相关分析及多元线性回归法评估大腿肌肉CSA、SMI、肌间FF、肌内FF与PT、TW的相关性。结果男性大腿CSA、PT、TW高于女性(P<0.05),肌间FF低于女性(P=0.005)。受试者大腿伸肌群CSA、SMI、PT高于屈肌群(P<0.001),肌内FF、肌间FF低于屈肌群(P<0.001)。受试者大腿屈、伸肌群肌内FF与PT呈中度负相关(r=-0.635,P<0.001;r=-0.546,P<0.001),与TW呈高、中度负相关(r=-0.718,P<0.001;r=-0.616,P<0.001);屈、伸肌群肌间FF与PT呈中度负相关(r=-0.519,P=0.003;r=-0.443,P=0.014),与TW呈低、中度负相关(r=-0.363,P=0.049;r=-0.552,P=0.002);屈、伸肌群CSA、SMI与PT、TW均无明显相关性(P均>0.05)。多元线性回归分析显示,肌内FF与屈、伸肌群的PT、TW显著相关[屈肌群:调整后R2(R^(2)_(adj))=0.505,P=0.001;R^(2)_(adj)=0.540,P<0.001;伸肌群:R^(2)_(adj)=0.351,P=0.006;R^(2)_(adj)=0.470,P=0.002]。结论基于IDEAL-IQ技术的FF可准确定量大腿肌间、肌内脂肪含量,且与等速肌力测试参数PT、TW存在负相关关系,其中以肌内FF明显。Objective To explore the value of iterative decomposition of water and fat with asymmetry and least squares estimation-quantitative fat imaging(IDEAL-IQ)in quantitative evaluation of thigh muscle fat content and its correlation with muscle strength in middle-aged and elderly volunteers.Methods From December 2020 to April 2021,30 volunteers aged 45 to 70 were recruited prospectively,including 15 males and 15 females with 52.5(49.0,56.3)years old.All subjects were scanned at 3.0 T MR,including axial T1WI,IDEAL-IQ and coronal T2WI of the left thigh.The region of interest of the knee extensors(quadriceps femoris)and knee flexors(hamstrings)in the left mid-thigh were delineated,and muscle cross-sectional area(CSA),skeletal muscle index(SMI),intermuscular fat fraction(FF)and intramuscular FF were obtained.In addition,isokinetic muscle strength measurement was performed on the left knee joint of all subjects at angular speeds of 60°/s and 180°/s to obtain peak torque(PT)and total work(TW)of knee flexors and extensors.Independent sample t-test,paired t-test or Mann-Whitney U test were used to compare the differences of CSA,SMI,intermuscular FF,intramuscular FF,PT and TW between different genders and muscle groups.Pearson or Spearman correlation analysis,and multiple linear regression analysis were used to analyze the correlation between CSA,SMI,intermuscular FF,intramuscular FF and PT,TW of thigh muscles.Results The CSA,PT and TW of thighs in males were higher than those in females(P<0.05),while the intermuscular FF in males was lower than that in females(P=0.005).The CSA,SMI and PT of the thigh extensors were higher than those of the flexors(P<0.001),while the intramuscular FF and intermuscular FF were lower than those of the flexors(P<0.001).Intramuscular FF of flexors and extensors were moderately negatively correlated with PT(r=-0.635,P<0.001;r=-0.546,P<0.001),and highly,moderately negatively correlated with TW(r=-0.718,P<0.001;r=-0.616,P<0.001).Intermuscular FF of flexors and extensors were moderately negatively c

关 键 词：肌 股 磁共振成像 等速肌力测试 

分 类 号：R445.2[医药卫生—影像医学与核医学]