腺苷负荷超声心动图在冠心病诊断中的评价研究  

Evaluation of Adenosine Load Echocardiography in the Diagnosis of Coronary Heart Disease

作　　者：孙雪林[1] 胡欣[1] 金鹏飞[1] SUN Xue-lin;HU Xin;JIN Peng-fei(Department of Pharmacy,Beijing Hospital/National Center of Gerontology/Institute of Geriatric Medicine,Chinese Academy of Medical Sciences/Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application(Beijing Hospital),Beijing 100730,China)

机构地区：[1]北京医院药学部,国家老年医学中心,中国医学科学院老年医学研究院,北京市药物临床风险与个体化应用评价重点实验室(北京医院),北京100730

出　　处：《中国合理用药探索》2022年第11期65-71,共7页Chinese Journal of Rational Drug Use

基　　金：国家重点研发计划资助项目(2020YFC2009000,2020YFC2009001)。

摘　　要：目的:探讨腺苷负荷超声心动图(ASE)在冠心病诊断中的应用价值。方法:计算机检索The Cochrane Library、Embase、PubMed、中国生物医学文献数据库、中国知网、万方数据库等,检索时间自建库至2022年2月,对检索结果进行人工筛查。英文检索词为“adenosine”“stress echocardiography”“cardiac stress test”。中文检索词为“腺苷负荷”“超声心动”“心脏负荷试验”。结果:腺苷在美国、欧洲、日本和中国被广泛推荐用于超声心动图药物负荷试验扩张冠脉血管,其具有良好的敏感性、特异性和准确性,且安全性较高,不良反应症状轻微,患者均能耐受,未见严重不良反应的发生。与同类药物相比,ASE结果的准确率和阳性率无统计学差异。结论:ASE用于诊断冠心病具有良好的敏感性、特异性和准确性,且安全性良好,推荐在临床推广使用。Objective:To investigate the value of adenosine stress echocardiography(ASE)in the diagnosis of coronary heart disease.Methods:The Cochrane Library,Embase,PubMed,China Biomedical Literature Database,CNKI,Wanfang and other databases were searched by computer from self-built database to February 2022,and the search results were manually screened.The English search words were“adenosine”“stress echocardiography”“cardiac stress test”.The Chinese search words were“adenosine load”“echocardiography”“cardiac load test”.Results:Adenosine in the United States,Europe,Japan and China are widely recommended for use in echocardiographic stress tests to dilate the coronary arteries,and the results showed that adenosine in load ultrasound examination had good sensitivity,specificity and accuracy with high security.Despitethe incidence of adverse reactions was high,but the symptoms were mild and patients could tolerate them,and no serious adverse reactions were observed.There was no significant difference in the accuracy and positive rate of ASE results compared with similar drugs.Conclusion:ASE has good sensitivity,specificity and accuracy in the diagnosis of coronary heart disease with high safety,and it can be considered for clinical application.

关 键 词：超声心动 腺苷 冠心病 药物负荷试验 药物评价 

分 类 号：R969.3[医药卫生—药理学]