梅毒血清固定患者神经梅毒患病率的Meta分析  

Prevalence of neurosyphilis among syphilis serofast patients:a Meta-analysis

作　　者：吴肖冰[1] 茅雅君 刘鑫 关杨[3] 郑锦芬[3] Wu Xiaobing;Mao Yajun;Liu Xin;Guan Yang;Zheng Jinfen(Department of Obesity and Metabolic Disease Prevention and Control,Shenzhen Center for Chronic Disease Control,Guangdong Shenzhen 518020,China;Shantou University Medical College,Guangdong Shantou 515041,China;Department of Dermatology,Shenzhen Center for Chronic Disease Control,Guangdong Shenzhen 518020,China)

机构地区：[1]深圳市慢性病防治中心肥胖与代谢性疾病防控科,广东深圳518020 [2]汕头大学医学院,广东汕头515041 [3]深圳市慢性病防治中心皮肤科,广东深圳518020

出　　处：《新发传染病电子杂志》2022年第4期65-69,共5页Electronic Journal of Emerging Infectious Diseases

基　　金：国家自科学基金项目(81903379);广东省医学科学技术研究基金(A2019440);深圳市医疗卫生三名工程(SZSM201611077);深圳市医学重点学科建设(SZXK065);深圳市卫生系统科研项目(SZXJ2018028)。

摘　　要：目的采用Meta分析方法估计梅毒血清固定患者中神经梅毒的患病情况,并分析其影响因素。方法检索中国期刊全文数据库、万方数据知识服务平台和PubMed数据库,收集有明确的梅毒血清固定和神经梅毒定义,且有报道血清固定病例数及神经梅毒病例数的文献。运用R软件进行统计分析。结果共检索到文献769篇,最终纳入文献23篇,涉及梅毒血清固定患者2103例,其中神经梅毒患者420例。使用随机效应模型计算梅毒血清固定患者中神经梅毒患病率为18%(95%CI:13%~25%)。血清固定患者的年龄(χ^(2)=104.82,P<0.001)和判断血清固定的随访时间(χ^(2)=139.44,P<0.001)不同,神经梅毒患病率存在统计学差异。脑脊液检测方法不同,神经梅毒检测阳性率也存在统计学差异(χ^(2)=137.86,P<0.001)。结论梅毒血清固定患者中神经梅毒患病率较高。应进一步加强梅毒血清固定与神经梅毒方面的研究,以期为制定梅毒防控政策提供科学依据。Objective To estimate the prevalence of neurosyphilis among syphilis serofast patients and analyze its associated factors using a meta-analysis approach.Method Key words with syphilis serofast and neurosyphilis were searched in the Chinese National Knowledge Infrastructure(CNKI),Wan Fang Database and PubMed.Literatures with clear definitions of syphilis serofast and neurosyphilis,and reporting the numbers of both serofast patients and neurosyphilis patients were collected.Statistical analysis was performed in the R software.Result A total of 769 literatures were retrieved,and 23 literatures were finally included.The included literatures involved 2103 syphilis serofast patients,among whom 420 were neurosyphilis patients.The prevalence of neurosyphilis among serofast patients was 18%(95%CI:13%to 25%)in the random-effects model.The prevalence rates varied with serofast patients'age(χ^(2)=104.82,P<0.001)and the follow-up time to define serofast(χ^(2)=139.44,P<0.001).The positive rates of neurosyphilis testing also varied with detection methods of cerebrospinal fluid(χ^(2)=137.86,P<0.001).Conclusion Syphilis serofast patients have high prevalence of neurosyphilis.It is necessary to conduct more researches on the relationships between syphilis serofast and neurosyphilis,and thus provide more scientific data for the formulation of syphilis prevention and control policies.

关 键 词：梅毒 血清固定 神经梅毒 META分析 

分 类 号：R759.13[医药卫生—皮肤病学与性病学]