2型糖尿病并发高尿酸血症患者血尿酸与粒淋比、γ-谷氨酰转肽酶的相关性及HUA发生的因素  

Correlation between serum uric acid,neutrophil-to-lymphocyte ratio andγ-glutamyl transpeptidase in patients with type 2 diabetes mellitus complicated with hyperuricemia and the influencing factors of hyperuricemia

作　　者：姚翡[1] 郁秋荣[1] 龚叶[1] 孔颖宏[1] YAO Fei;YU Qiu-rong;GONG Ye;KONG Ying-hong(Department of Endocrinology,the Second People′s Hospital of Changshu City,Jiangsu Province,Changshu 215500,China)

机构地区：[1]江苏省常熟市第二人民医院内分泌科,江苏常熟215500

出　　处：《河北医科大学学报》2022年第10期1147-1152,共6页Journal of Hebei Medical University

基　　金：常熟市科技发展计划(社会发展)项目(CS201821)。

摘　　要：目的研究2型糖尿病并发高尿酸血症患者血尿酸与粒淋比和γ-谷氨酰转肽酶的相关性及高尿血酸症发生的影响因素。方法选取江苏省常熟市第二人民医院内分泌代谢科门诊及住院的2型糖尿病患者270例,根据是否合并高尿酸血症,将患者分成仅糖尿病组和合并组;同时选择同期在本院行身体检查的60名健康志愿者为对照组。比较3组受试者血尿酸、粒淋比和γ-谷氨酰转肽酶的表达,Pearman法分析血尿酸与粒淋比和γ-谷氨酰转肽酶的相关性。单因素和非条件Logistic回归分析确定高尿酸血症发生的独立影响因素。结果3组受试者血尿酸、粒淋比和γ-谷氨酰转肽酶差异有统计学意义(F=451.351,78.706,314.433,P<0.001);合并组患者血尿酸、粒淋比和γ-谷氨酰转肽酶明显高于仅糖尿病组和对照组,仅糖尿病组患者血尿酸、粒淋比和γ-谷氨酰转肽酶明显高于对照组。血尿酸与粒淋比和γ-谷氨酰转肽酶均呈现正相关(r=0.423,0.730,P<0.001)。两组患者在高血压(χ^(2)=89.708,P<0.001)、高血脂(χ^(2)=5.575,P=0.018)、脂肪肝(χ^(2)=7.614,P=0.006)、视网膜病变(χ^(2)=110.174,P=0.000)、下肢血管病变(χ^(2)=14.110,P=0.000)、冠状动脉粥样硬化性心脏病(χ^(2)=35.042,P<0.001)、病程(t=8.242,P<0.001)、糖化血红蛋白(t=10.697,P<0.001)、空腹血糖(t=11.510,P<0.001)、三酰甘油(t=22.108,P<0.001)、高密度脂蛋白(t=4.488,P<0.001)、低密度脂蛋白(t=2.006,P=0.048)、血肌酐(t=5.691,P<0.001)、舒张压(t=7.835,P<0.001)等差异存在统计学意义。Logistic回归显示,年龄(OR=1.208,95%CI:1.013~1.441)、病程(OR=1.536,95%CI:1.188~1.985)、糖化血红蛋白(OR=2.184,95%CI:1.473~3.238)、粒淋比(OR=2.977,95%CI:1.889~4.691)和γ-谷氨酰转肽酶(OR=1.655,95%CI:1.363~2.010)是发生高尿血酸症的独立影响因素(P<0.05)。结论2型糖尿病并发高酸血症患者血尿酸与粒淋比和γ-谷氨酰转肽酶呈正相关,年龄、病程、糖化血红蛋�Objective To explore the correlation between serum uric acid(UA),neutrophil-to-lymphocyte ratio(NLR),andγ-glutamyl transpeptidase(γ-GT)in patients with type 2 diabetes mellitus(T2DM)complicated with hyperuricemia and the influencing factors of hyperuricemia.Methods A total of 270 outpatients and inpatients with T2DM treated in the Second People′s Hospital of Changshu City,Jiangsu Province were selected.According to presence or absence of hyperuricemia,the patients were divided into diabetic group and combination group.Another 60 healthy volunteers who underwent physical examination in our hospital during the same period were selected as the control group.The expression of serum UA,NLR andγ-GT in the three groups was compared,and the correlation between serum UA,NLR andγ-GT was analyzed by Pearman method.Univariate and unconditional Logistic regression analyses were used to determine the independent influencing factors of hyperuricemia.Results The differences in serumUA,NLR andγ-GT were statistically significant in three groups(F=451.351,78.706,314.433,P<0.001).SerumUA,NLR andγ-GT were significantly higher in the combination group than in the diabetic group and the control group,and serum UA,NLR andγ-GT in the diabetic group were significantly higher than those in the control group.Blood UA was positively correlated with NLR andγ-GT(r=0.423,0.730,P<0.001).There were significant differences in the two groups with respect to hypertension(χ^(2)=89.708,P<0.001),hyperlipidemia(χ^(2)=5.575,P=0.018),fatty liver(χ^(2)=7.614,P=0.006),retinopathy(χ^(2)=110.174,P<0.001),lower limb vascular disease(χ^(2)=14.110,P<0.001),coronary atherosclerotic heart disease(χ^(2)=35.042,P<0.001),course of disease(t=8.242,P<0.001),glycated hemoglobin(t=10.697,P<0.001),fasting glucose(t=11.510,P<0.001),triacylglycerol(t=22.108,P<0.001),high-density lipoprotein(t=4.488,P<0.001),low-density lipoprotein(t=2.006,P=0.048),blood creatinine(t=5.691,P<0.001)and diastolic blood pressure(t=7.835,P<0.001).Logistic regression showed that t

关 键 词：糖尿病 2型 高尿酸血症 尿酸 

分 类 号：R587.1[医药卫生—内分泌]