低共熔溶剂在生物催化中的应用研究进展  

Research Progress on the Properties of Deep Eutectic Solvents and Their Application in Biocatalysis

作　　者：仝争 王渝 何晓希 赵祥杰 王朝宇 杨荣玲 谢烨晴 TONG Zheng;WANG Yu;HE Xiao-xi;ZHAO Xiang-jie;WANG Zhao-yu;YANG Rong-ling;XIE Ye-qing(School of Life Science and Food Technology,Huaiyin Institute of Technology,Huai′an 223003,China)

机构地区：[1]淮阴工学院生命科学与食品工程学院,江苏淮安223003

出　　处：《化学试剂》2022年第12期1723-1730,共8页Chemical Reagents

基　　金：国家自然科学基金项目(21706088);江苏省六大人才高峰项目(2018-SWYY-020)。

摘　　要：近年来,新型低共熔溶剂(Deep eutectic solvents,DESs)不断开发,已成为替代传统有机溶剂和离子液体的一种绿色溶剂,其具有熔点低、不易挥发、易合成、成本低、易回收等优点,在生物催化反应中具有重要的应用前景。对不同DESs的结构及类型进行了总结,并对其密度、粘度、导电性、凝固点、热稳定性等理化性质进行了详细说明,进而对其细胞毒性和生物降解性进行了阐述,重点对其在酯交换反应、还原反应、水解反应等生物催化反应中的应用进行了总结,进一步对存在的问题和研究的方向进行了总结和展望。New deep eutectic solvents(DESs)have been continuously developed in recent years,which have been shown to be a kind of green solvents that could replace traditional organic solvents and ionic liquids in biological catalysis reactions.DESs have displayed the advantages of low melting point,non-volatile,easy synthesis,low cost and easy recovery properties.They have important application prospects in biocatalytic reactions.The structure and types of different DESs summarized and its physical and chemical properties such as density,viscosity,conductivity,freezing point and thermal stability were described in detail.And,the cytotoxicity and biodegradability characteristics of DESs were also introduced,with emphasis on its application in biocatalytic reactions such as esterification reaction,reduction reaction and hydrolysis reaction.Further,the existing problems and research directions are summarized and prospected.

关 键 词：低共熔溶剂 性质 生物催化 细胞毒性 生物降解性 

分 类 号：TQ413[化学工程]