2005—2020年河南省两次及以上细菌性痢疾发病病例流行特征分析  

Analysis of epidemiological characteristics of bacillary dysentery with multiple-onset in Henan Province from 2005 to 2020

作　　者：李亚飞 王文华 范威 王莹莹 胡晓 张白帆[1] 尤爱国[1] 景怀琦[2] 王海峰[1] 叶莹[1] 黄学勇[1] Yafei Li;Wenhua Wang;Wei Fan;Yingying Wang;Xiao Hu;Baifan Zhang;Aiguo You;Huaiqi Jing;Haifeng Wang;Ying Ye;Xueyong Huang(Institute for Infectious Disease Control and Prevention,Henan Provincial Center for Disease Control and Prevention,Henan Key Laboratory of Pathogenic Organism,Zhengzhou 450016,China;National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China)

机构地区：[1]河南省疾病预防控制中心传染病预防控制所河南省传染病病原生物重点实验室,郑州450016 [2]中国疾病预防控制中心传染病预防控制所,北京102206

出　　处：《中华预防医学杂志》2022年第10期1472-1477,共6页Chinese Journal of Preventive Medicine

基　　金：国家科技重大专项(2018ZX10713003-002-003);国家自然科学基金(81573204, 81773500);河南省中青年卫生健康科技创新领军人才培养项目(YXKC2020006);河南省重大科技专项(211100311000);河南省医学科技攻关计划联合共建项目(LHGJ20220160)。

摘　　要：目的了解2005—2020年河南省细菌性痢疾两次及以上发病病例的流行特征。方法通过中国疾病预防控制中心疾病监测信息报告管理系统收集2005年1月至2020年12月河南省细菌性痢疾报告病例(包括确诊病例和临床诊断病例), 主要信息包括性别、年龄、家庭住址、发病日期和诊断日期等, 将同一病例两次发病时间间隔在15 d以上判定为两次发病。对2005—2020年河南省细菌性痢疾两次及以上发病患者的发病特征进行分析, 同时采用ArcGIS软件绘制病例地区分布图。结果 2005—2020年河南省累计报告细菌性痢疾病例250 430例, 累积发病率为228.66/10万。两次及以上发病病例共计2 342例;细菌性痢疾病例中两次及以上发病病例的发生率逐年升高(趋势χ2=2 932.28, P<0.001);不同性别两次及以上发病病例的发生率差异无统计学意义(χ2=0.39, P=0.540);不同年龄组间的发生率差异有统计学意义(χ2=438.40, P<0.001), 60~69岁年龄组两次及以上发病的发生率较高(1.70%);病例发病时间间隔最短为16 d, 最长为5 579 d, M(Q1, Q3)为428(237, 843)d。与健康人群相比, 有细菌性痢疾患病史的人群再次罹患细菌性痢疾的风险更高(RR:4.12, 95%CI:3.95~4.29)。结论 2005—2020年河南省两次及以上细菌性痢疾发病病例呈逐年增加的趋势, 且存在年龄差异。Objective To understand the epidemiological characteristics of bacillary dysentery with multiple-onset in Henan province from 2005 to 2020.Methods The reported cases of bacillary dysentery(including confirmed cases and clinically diagnosed cases)in Henan Province from January 2005 to December 2020 were collected through China′s National Disease Supervision Information Management System.The main information included gender,age,home address,date of onset and date of diagnosis.The interval between two episodes of the same case was more than 15 days,which was judged as two episodes.The incidence characteristics of bacillary dysentery patients with two or more cases in Henan Province from 2005 to 2020 were analyzed,and the regional distribution map of cases was drawn using ArcGIS software.Results From 2005 to 2020,a total of 250430 cases of bacillary dysentery were reported in Henan Province,with a cumulative incidence rate of 228.66/100000.There were 2342 cases with two or more attacks.The incidence of recurrent cases of bacillary dysentery increased year by year(χ2trend=2932.28,P<0.001).There was no significant difference in the incidence of two or more cases of different sexes(χ2=0.39,P=0.540).There was significant difference in the incidence among different age groups(χ2=438.40,P<0.001).The incidence of two or more cases in the 60-69 age group was relatively high(1.70%).The shortest time interval between the onset of the disease was 16 days,and the longest was 5579 days,with M(Q1,Q3)about 428(237,843)days.Compared with healthy people,those with a history of bacterial diseases had a higher risk of developing bacillary dysentery(RR:4.12,95%CI:3.95‒4.29).Conclusion The proportion of patients with multiple-onset shows an increasing trend,and there is an age difference.

关 键 词：志贺菌 痢疾 多次发病 流行特征 

分 类 号：R516.4[医药卫生—内科学] R181.3[医药卫生—临床医学]