Epigenetic connection between gut microbiota-derived short-chain fatty acids and chromatin histone modification in kidney diseases  

作　　者：Lingzhi Li Shenyu Zhao Ting Xiang Han Feng Liang Ma Ping Fu 

机构地区：[1]Division of Nephrology,Kidney Research Institute,West China Hospital of Sichuan University,Chengdu,Sichuan 610041,China [2]Department of Cardiovascular Medicine,West China Hospital of Sichuan University,Chengdu,Sichuan 610041,China [3]Department of Biostatistics and Data Science,School of Public Health,University of Texas Health Science Center at Houston,Houston,TX,USA

出　　处：《Chinese Medical Journal》2022年第14期1692-1694,共3页中华医学杂志（英文版）

基　　金：supported by the National Key R&D Program of China(No.2020YFC2005000);the National Science Foundation of China(No.82100775).

摘　　要：Gut microbiota-derived metabolites influence host physiology and pathology,where short-chain fatty acids(SCFAs)are the main class of gut microbiota-derived metabolites.[1]SCFAs are fatty acids containing 1 to 6 carbon atoms,including acetate,propionate,butyrate,and pentanoate,which provide 6%to 10%of the body’s total daily energy and 60%to 70%of the colonic epithelial energy needed.[2]Anaerobic bacteria principally generate the SCFAs[1]in the intestine.Once produced,SCFAs are mainly absorbed in the colon(90%–95%),reach circulation,and play roles for distal organs and tissues.[2]

关 键 词：ORGANS INTESTINE COLON 

分 类 号：R692[医药卫生—泌尿科学]