杀菌剂肟菌酯的合成工艺优化  

Synthesis optimization of trifloxystrobin

作　　者：郭建法 王涛 GUO Jianfa;WANG Tao(Liaoning Zhonghui Biotechnology Co.,Ltd.,Fuxin 123129,Liaoning,China)

机构地区：[1]辽宁众辉生物科技有限公司,辽宁阜新123129

出　　处：《世界农药》2022年第11期36-40,共5页World Pesticide

摘　　要：为降低肟菌酯生产成本,对其合成工艺进行优化。以溴化物和间三氟甲基苯乙酮肟为原料,缩合反应合成肟菌酯,研究物料配比、反应温度、溶剂种类等对反应收率与含量的影响。采用“一锅投”方式,以三辛基甲基氯化铵为催化剂,甲基异丁基酮为溶剂,碳酸钠为缚酸剂,优化条件下,肟菌酯收率83.5%,含量98.3%。该合成方法收率高,工艺简单,适合工业化开发。This paper aims to develop a new synthetic method of trifloxystrobin to reduce the cost.With bromide and m-trifluoromethylacetophenone oxime as raw materials,the influence factors of the last condensation such as material ratio,reaction temperature and different solvents were studied.Using one-pot feeding method,trioctyl methyl ammonium chloride as catalyst,methyl isobutyl ketone as solvent,sodium carbonate as acid binding agent,the yield of trifloxystrobin was 83.5%and the content was 98.3%under the optimized condition.This new synthetic method had the advantages of high yield,simple process and was suitable to be applied in industry.

关 键 词：肟菌酯 杀菌剂 合成 

分 类 号：TQ455[化学工程—农药化工]