3-甲基-4-硝基亚胺基氢化-1,3,5-噁二嗪的连续流微通道合成研究  

Study on continuous flow microchannel synthesis of 3-methyl-4-nitroiminohydro-1,3,5-oxadiazine

作　　者：刘长明 刘景阔 方慧慧 LIU Changming;LIU Jingkuo;FANG Huihui(Ningxia Soochow Agrochemical Co.,Ltd.,Yinchuan 751600,China)

机构地区：[1]宁夏东吴农化股份有限公司,银川751600

出　　处：《世界农药》2022年第11期41-43,60,共4页World Pesticide

摘　　要：3-甲基-4-硝基亚胺基氢化-1,3,5-噁二嗪(噁二嗪)是合成噻虫嗪的重要中间体,为解决其传统釜式间歇工艺反应时间长和收率较低等缺点,基于间歇釜式反应条件,采用当前流行的微通道反应器进行了以甲基硝基胍与多聚甲醛制备噁二嗪试验研究,并取得理想结果。与间歇釜式反应相比,反应时间由16 h降为反应停留时间25 s,反应收率由79%提高到92%。3-Methyl-4-nitroiminohydro-1,3,5-oxadiazine(oxadiazine)is an important intermediate for the synthesis of thiamethoxam.In order to solve the shortcomings of its traditional batch reactor process,such as long reaction time and low yield,based on the batch reactor reaction conditions,the current popular microchannel reactor was used to conduct an experimental study on the preparation of oxadiazine from methylnitroguanidine and paraformaldehyde,and achieved ideal results.Compared with the batch reactor reaction,the reaction time was reduced from 16 h to 25 s,and the reaction yield was increased from 79%to 92%.

关 键 词：噁二嗪 新烟碱类杀虫剂 微通道反应器 连续微通道合成 

分 类 号：TQ450[化学工程—农药化工]