血液透析对糖尿病肾衰竭患者炎症因子及肾功能的影响  

Effects of Hemodialysis on Inflammatory Factors and Renal Function in Diabetic Renal Failure

作　　者：李春利 Li Chunli(Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第五附属医院,河南郑州450000

出　　处：《哈尔滨医药》2022年第6期15-17,共3页Harbin Medical Journal

摘　　要：目的 探讨血液透析对糖尿病肾衰竭患者的疗效。方法 选择我院收治的糖尿病肾衰竭患者70例,采用随机数字表法分为两组,各35例。对照组采用常规血液透析,观察组采用联机血液透析滤过,比较两组炎症因子水平及肾功能。结果观察组治疗后肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、C反应蛋白(C-reactive protein,CRP)及白细胞介素-6(Inter leukin 6,IL-6)水平均低于对照组,差异有统计学意义(t=6.638、5.796、19.575,P<0.001);观察组治疗后24h尿蛋白定量(24-hour urinary protein quantity,24hUPQ)、血肌酐(Serum creatinine,Scr)、胱抑素C(CystatinC,CysC)、尿素氮(Blood urea nitrogen,BUN)水平均低于对照组,差异有统计学意义(P<0.05)。结论 血液透析可降低糖尿病肾衰竭患者的炎症因子水平,改善其肾功能,而联机血液透析滤过效果优于常规血液透析。Objective To investigate the effect of hemodialysis on diabetic renal failure.Methods 70 patients with diabetic renal failure were selected and divided into two groups by random number table method,35 cases in each group.The control group received routine hemodialysis,and the observation group received on-line hemodiafiltration.The levels of inflammatory factors and renal function were compared between the two groups.Results The levels of Tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)and Inter leukin-6(IL-6)in the observation group were lower than those in the control group.The difference was statistically significant(t=6.638,5.796,19.575,all P=0.000).In observation group,24-hour Urinary Protein Quantity(24hUPQ),Serum creatinine(Scr),CystatinC(cystatin inc)were determined at 24h after treatment.CysC)and Blood urea nitrogen(BUN)levels were lower than those in the control group,with statistical significance(P<0.05).Conclusion Hemodialysis can reduce the level of inflammatory factors and improve renal function in diabetic renal failure patients,and the effect of on-line hemodiafiltration is better than that of conventional hemodialysis.

关 键 词：糖尿病 肾衰竭 血液透析 炎症因子 肾功能 

分 类 号：R587.1[医药卫生—内分泌]