结缔组织病合并肺孢子菌肺炎的临床特征和诊疗  

Clinical characteristics, diagnosis and treatment of pneumocystis jirovecii pneumonia infection in patients with connective tissue diseases

作　　者：朱盈姿 董凌莉[1] ZHU Ying-zi;DONG Ling-li(Department of Rheumatology and Immunology,Tongji Hospital,Tongji Medical College,Huazhong Universtiy of Science and Technology,Hubei Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院风湿免疫科,湖北武汉430030

出　　处：《内科急危重症杂志》2022年第5期368-373,共6页Journal of Critical Care In Internal Medicine

摘　　要：耶氏肺孢子菌肺炎(PJP)是感染人类免疫缺陷病毒(HIV)患者中最常见的机会性感染。近年来,PJP在非HIV患者中发病率逐渐增加,其中结缔组织病(CTD)患者中PJP感染已引起临床重视,多项研究对CTD患者合并PJP感染的病例进行了报道。本文对CTD患者合并PJP感染的临床特点、起病和预后危险因素、诊断及治疗经验等方面进行了系统综述,旨在为CTD患者接受免疫抑制治疗过程中及时识别PJP感染、把握治疗时机提供有用临床信息。Pneumocystis jirovecii pneumonia(PJP)is the most common opportunistic infection among people infected with human immunodeficiency virus(HIV).In recent years,the incidence of PJP in non-HIV patients has gradually increased,among which,PJP infection in patients with connective tissue diseases(CTD)has aroused clinical attention,and a number of studies have reported cases of CTD patients with PJP infection.In this review,the clinical characteristics,risk factors for onset and prognosis,diagnosis and treatment experience of PJP infection in CTD patients were systematically reviewed,aiming to provide useful clinical information for timely identification of PJP infection in CTD patients undergoing immunosuppressive therapy and grasping the timing of treatment.

关 键 词：结缔组织病 肺孢子菌肺炎 临床特征 

分 类 号：R593.2[医药卫生—内科学] R563.1[医药卫生—临床医学]