The molecular mechanism of natural short sleep:A path towards understanding why we need to sleep  

作　　者：Liubin Zheng Luoying Zhang 

机构地区：[1]Key Laboratory of Molecular Biophysics of Ministry of Education,College of Life Science and Technology,Huazhong University of Science and Technology,Wuhan 430074,Hubei,China [2]Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration,Wuhan 430022,Hubei,China

出　　处：《Brain Science Advances》2022年第3期165-172,共8页神经科学（英文）

基　　金：supported by grants from the Ministry of Science and Technology of China(Grant No.2021ZD0203202);the Natural Science Foundation of China(Grant Nos.31930021 and 32022035)。

摘　　要：Sleep constitutes a third of human life and it is increasingly recognized as important for health.Over the past several decades,numerous genes have been identified to be involved in sleep regulation in animal models,but most of these genes when disturbed impair not only sleep but also health and physiological functions.Human natural short sleepers are individuals with lifelong short sleep and no obvious adverse outcomes associated with the lack of sleep.These traits appear to be heritable,and thus characterization of the genetic basis of natural short sleep provides an opportunity to study not only the genetic mechanism of human sleep but also the relationship between sleep and physiological function.This review focuses on the current understanding of mutations associated with the natural short sleep trait and the mechanisms by which they contribute to this trait.

关 键 词：SLEEP DURATION NATURAL SHORT SLEEP SHORT SLEEPER gene mutation 

分 类 号：R338.63[医药卫生—人体生理学]