1,2,2-三芳基乙酮化合物合成方法研究进展  

Recent advances in the synthesis of 1,2,2-triarylacetophenones

作　　者：缪存静 姚佳琪 Cunjing Miao;Jiaqi Yao(Department of Pharmacy,Xiasha Campus,Sir Run Run Shaw Hospital,College of Medicine,Zhejiang University,Hangzhou 310018,China;Department of Pharmacy,Ningbo Huamei Hospital,University of Chinese Academy of Sciences,Ningbo 315000,China)

机构地区：[1]浙江大学医学院附属邵逸夫医院下沙院区药学部,杭州310018 [2]中国科学院大学宁波华美医院药学部,宁波315000

出　　处：《中国科学：化学》2022年第10期1803-1823,共21页SCIENTIA SINICA Chimica

摘　　要：1,2,2-三芳基乙酮化合物是合成众多天然产物和上市药物的重要中间体,也被广泛应用于生物、农药、高分子以及材料科学等众多领域,具有广阔的发展前景.因此,发展简便、高效的方法实现该类化合物的不对称合成具有重要的理论和现实意义.近20年来,芳基乙酮类化合物合成工作取得了重要进展.本文根据合成策略的不同对反应进行分类,并综述了1,2,2-三芳基乙酮化合物合成方法研究进展,详细讨论了反应底物普适性、机理和应用,并对该领域的发展前景和局限性进行了总结.1,2,2-Triarylacetophenone compounds are important intermediates for the synthesis of many natural products and marketed drugs,and they are also widely used in many fields such as biology,pesticides,polymers and materials science,which have great prospects.Therefore,it is of great theoretical and practical significance to develop simple and efficient methods for the asymmetric synthesis of these compounds.In the past two decades,important progress has been made in the synthesis of aryl acetophenones.In this review,the reactions are classified according to different synthesis strategies,and the progress of synthesis methods of 1,2,2-triarylacetophenone compounds is summarized.The reaction substrate compatibility,mechanism,applications,development prospects and limitations in this field are also discussed in detail.

关 键 词：1 2 2-三芳基乙酮 合成方法 重要中间体 不对称合成 

分 类 号：TQ244.2[化学工程—有机化工]