经方及其共有黄酮类成分抗抑郁机制研究进展  

Research progress on the pharmacodynamic mechanism of antidepressant compound prescriptions and its flavonoids active ingredients

作　　者：郝闻致 王璐[1] 黄俊卿 陈家旭 HAO Wen-zhi;WANG Lu;HUANG Jun-qing;CHEN Jia-xu(Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine,Jinan University,Guangzhou 510632,China;School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]暨南大学,广州市中医方证重点实验室,广东广州510632 [2]北京中医药大学中医学院,北京100029

出　　处：《药学学报》2022年第10期3035-3046,共12页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(82174278,82074300);广东省重点领域研发计划(2020B1111100001);广州市中医方证重点实验室(202102010014);广东省中医药信息化重点实验室(2021B1212040007);暨南大学黄振东中医医学研究基金(201911);王宽诚青年学者项目。

摘　　要：抑郁症是以长久的情绪低落,伴有认知、睡眠与社交障碍的精神疾病。抑郁症在中医属“郁证”、“脏躁”、“癫狂”等范畴,以肝郁脾虚为主要证型,以疏肝解郁、养血健脾为主要治则。逍遥散、四逆散、柴胡疏肝散等是中医临床治疗抑郁症的经方。临床与基础研究表明,经方共有的黄酮类成分具有抗炎、抗氧化、神经保护等药理作用,能从不同作用途径预防和抑制抑郁症的发生发展。基于此,本综述围绕抑郁症的发病机制,总结和讨论了抗抑郁经方及其共有黄酮类成分的抗抑郁作用及机制,以期为抑郁症的防治提供思路。Depression is a psychiatric disease characterized by long-lasting low mood,accompanied by symptoms such as cognitive,sleep and social disturbances.In the theory of traditional Chinese medicine,depression is included in the categories of"depression syndrome"and"madness",and the main syndrome type is liver stagnation and spleen deficiency.Xiaoyao san,Sini san and Chaihushugan san are commonly used prescriptions for clinical treatment of depression,and flavonoids are the common active ingredients.Clinical and basic studies have shown that the flavonoids derived from antidepressant compound prescription have pharmacological effects such as antiinflammatory,antioxidant,neuroprotective,and intestinal flora regulation which could prevent the occurrence and development of depression from different pathways.Based on this,this review focuses on the pathogenesis of depression,summarizes the common flavonoids in antidepressant prescriptions,and summarizes their regulatory mechanisms and effects in order to provide ideas for the prevention and treatment of depression.

关 键 词：抑郁症 黄酮类成分 神经递质 氧化应激 神经炎症 

分 类 号：R966[医药卫生—药理学]