丁基苯酞在脑血管病的药理作用及临床联合应用的研究进展  

Research progress on pharmacological effects and clinical combined application of 3-n-butylphthalide in cerebrovascular diseases

作　　者：泥文娟 李伟霞[2] 王晓艳[2] 吴娅丽 韩冰 贾金浩 李琨 纪秋如 唐进法[2] NI Wen-juan;LI Wei-xia;WANG Xiao-yan;WU Ya-li;HAN Bing;JIA Jin-hao;LI Kun;JI Qiu-ru;TANG Jin-fa(Henan University of Chinese Medicine,Zhengzhou 450046,China;Henan Province Engineering Research Center of Clinical Application,Evaluation and Transformation of Traditional Chinese Medicine,Henan Provincial Key Laboratory for Clinical Pharmacy of Traditional Chinese Medicine,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学,河南郑州450046 [2]河南中医药大学第一附属医院,河南省中药临床应用、评价与转化工程研究中心,河南省中药临床药学中医药重点实验室,河南郑州450000

出　　处：《药学学报》2022年第10期3047-3056,共10页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金青年基金资助项目(82004082);国家自然科学基金河南省人才培养联合基金资助项目(U1504827);河南省中医药拔尖人才培养项目(豫中医科教[2018]35号)。

摘　　要：脑血管病具有发病率高、致残致死率高及复发率高等特点,严重危害人类健康,增加国民卫生经济负担。丁基苯酞是临床常用的治疗脑血管疾病的一类新药,也是当归、川芎等中药中的主要活性成分之一。本文对丁基苯酞的药理作用进行了系统概述,其具有抗血小板聚集、抗血栓形成、抑制神经细胞凋亡、抗氧化、抗脑缺血、减轻脑损伤、抗血管性痴呆等药理作用,其临床常与依达拉奉、阿替普酶、法舒地尔、醒脑静注射液、复方丹参注射液等药物联合使用治疗脑卒中、血管性痴呆、脑血管痉挛等脑血管疾病,并发挥较好的协同治疗作用,可为丁基苯酞的临床合理应用提供支撑。Cerebrovascular diseases have the characteristics of high morbidity,high disability,high mortality and high recurrence rate,which seriously harm human health and increase the national health economic burden.3-n-Butylphthalide(NBP)is a new drug commonly used in clinical treatment of cerebrovascular diseases,and it is also one of the main active components in traditional Chinese medicine such as Angelica sinensis and Chuanxiong.In this review,the pharmacological effects of NBP were systematically summarized.Studies have shown that NBP has pharmacological effects such as antiplatelet aggregation,anti-thrombosis,inhibiting neuronal apoptosis,antioxidation,anti-cerebral ischemia,anti-brain injury,and anti-vascular dementia.In clinical practice,it is often combined with edaravone,alteplase,fasudil,Xingnaojing injection,and compound Danshen injection to treat cerebral vascular diseases such as stroke,vascular dementia,and cerebral vasospasm,and plays a good synergistic effect.This summary could provide support for the rational clinical application of NBP,and also provide basis for the in-depth study of the interaction of its drug combination.

关 键 词：丁基苯酞 脑血管病 药理作用 临床联合应用 

分 类 号：R966[医药卫生—药理学]