续断及其有效成分的抗痴呆作用及研究进展  

Research progress on the anti-dementia effect of Dipsaci Radix and its active compounds

作　　者：崔金帅 刘妍 王子颖 陈刚 CUI Jin-shuai;LIU yan;WANG Zi-ying;CHENG Gang(Interdisciplinary Institute of Individualized Prevention and Treatment of Encephalopathy,School of Traditional Chinese Medicine,Jinan University,Guangzhou 510632,China;Key Laboratory of Endemic and Minority Diseases of Ministry of Education,Guizhou Medical University,Guiyang 550004,China)

机构地区：[1]暨南大学中医学院,脑病个性化防治跨学科研究所,广东广州510632 [2]地方病与少数民族疾病教育部重点实验室(贵州医科大学),贵州贵阳550004

出　　处：《药学学报》2022年第10期3057-3066,共10页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(82104416);中央高校基本科研业务费专项资金资助项目(21621005);广东省基础与应用基础研究基金(2021A1515110571);(贵州医科大学)地方病与少数民族疾病教育部重点实验室开放基金资助项目(FZSW-2021-001)。

摘　　要：痴呆是由脑部疾病引起的严重认知功能障碍的一系列疾病,中医认为与肾的亏虚密切相关,阿尔茨海默病(Alzheimer’s disease,AD)、脑卒中(cerebral stroke)引起的痴呆及血管性痴呆(vascular dementia,VAD)等是最常见的痴呆类型。续断(Dipsaci Radix)是川续断科植物川续断(Dipsacus asper Wall.ex Henry)的干燥根,具有补肝肾、强筋骨、通血脉的功效。续断包含三萜皂苷类、环烯醚萜苷类等主要化学成分,近年来研究发现续断及其有效成分具有改善痴呆的作用,其多靶点的分子机制值得深入研究。本综述将通过总结分析近年来续断改善痴呆的研究报道,为进一步挖掘其在痴呆防治上的机制及应用提供参考。Dementia is a series of diseases with severe cognitive decline caused by brain diseases,that closely related to kidney deficiency in traditional Chinese medicine,including Alzheimer’s disease(AD),dementia caused by cerebral stroke,vascular dementia(VAD)and so on.Dipsaci Radix is the dried root of Dipsacus asper Wall.ex Henry and its curative effects mainly focus on nourishing the liver and kidney,strengthening muscles and bones,as well as dredging blood vessels.The main chemical components of Dipsaci Radix are triterpenoid saponins and iridoid glycosides.In recent years,studies have found that Dipsaci Radix and its active compounds could ameliorate dementia symptoms via multiple targets and molecular mechanisms.In this review,we summarize the recent research progress of Dipsaci Radix in dementia prevention,which will provide reference for further exploration of its mechanism and application in the prevention and treatment of dementia.

关 键 词：续断 痴呆 阿尔茨海默病 脑卒中 血管性痴呆 

分 类 号：R966[医药卫生—药理学]