山蜡梅叶中1个新的愈创木烷型倍半萜  

A new guaiane-sesquiterpenoid from the leaves of Chimonanthus nitens Oliv.

作　　者：郭娜 吴华强[1] 舒任庚 GUO Na;WU Hua-qiang;SHU Ren-geng(School of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang 330004,China)

机构地区：[1]江西中医药大学药学院,江西南昌330004

出　　处：《药学学报》2022年第10期3168-3172,共5页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81360631);江西省重点研发计划项目(20203BBGL73218)。

摘　　要：运用硅胶柱色谱、ODS柱色谱、Sephadex LH-20柱色谱及半制备高效液相等多种色谱分离技术,从山蜡梅叶中分离得到9个化合物,通过质谱、核磁共振波谱以及单晶衍射数据,分别鉴定为:chimnitensene B(1)、1α-hydroxyisodauc-4-en-15-al(2)、trans-4,5-dihydroxycorocalane(3)、trefoliol B(4)、oplopanone(5)、oplodiol(6)、3-(3’-hydroxybutyl)-2,4,4-trimethylcyclohexa-2,5-dienone(7)、9(S)-4-oxo-7,8-dihydro-β-ionol(8)和saniculamoid D(9)。其中,化合物1为新的愈创木烷型倍半萜,化合物2~9为首次从山蜡梅植物中分离得到。Nine compounds were isolated from the leaves of Chimonanthus nitens Oliv.by silica gel,ODS,Sephadex LH-20 column chromatography and semi-preparative HPLC.They were identified as chimnitensene B(1),1α-hydroxyisodauc-4-en-15-al(2),trans-4,5-dihydroxycorocalane(3),trefoliol B(4),oplopanone(5),oplodiol(6),3-(3’-hydroxybutyl)-2,4,4-trimethylcyclohexa-2,5-dienone(7),9(S)-4-oxo-7,8-dihydro-β-ionol(8),and saniculamoid D(9)respectively,by MS,NMR and single crystal diffraction.Among them,compound 1 is a new guaianesesquiterpenoid,and compounds 2-9 were isolated from this plant for the first time.

关 键 词：山蜡梅 倍半萜类 chimnitensene B 

分 类 号：R284[医药卫生—中药学]