支气管哮喘气道黏液栓的研究进展  

Progress of airway mucus plugs in bronchial asthma

作　　者：刘婷婷(综述)[1] 殷菊[1] 郭琰[1] 申昆玲(审校)[1,2] Liu Tingting;Yin Ju;Guo Yan;Shen Kunling(China National Clinical Research Center of Respiratory Diseases,Respiratory Department of Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,Beijing 100045,China;Department of Respiratory,Shenzhen Children′s Hospital,Shenzhen 518038,China)

机构地区：[1]国家儿童医学中心,首都医科大学附属北京儿童医院呼吸科,国家呼吸系统疾病临床医学研究中心,100045 [2]深圳市儿童医院呼吸科,518038

出　　处：《国际儿科学杂志》2022年第9期582-586,共5页International Journal of Pediatrics

基　　金：国家重点研发计划(2016YFC0901103)。

摘　　要：黏液栓是致死性哮喘的特征,是患者气道内积聚的异常黏稠的黏液。对哮喘患者气道黏液栓的研究可追溯到100年前。伴有黏液栓的哮喘患者除原发病表现外,还可出现哮喘的急性加重或治疗效果不佳,此时,应警惕黏液栓的存在,可应用多层螺旋计算机断层成像识别和评估黏液栓。该文综述了气道黏液的产生,介绍了哮喘患者黏液栓的形成机制、临床特点以及黏液栓的识别和评分系统,并对黏液栓的鉴别诊断和治疗进行总结。Mucus plugs is a feature of fatal asthma,which is the abnormally thick mucus accumulated in the airway of patients.The study of airway mucus plugs in asthmatic patients began 100 years ago.In addition to the manifestation of primary disease,asthma patients with mucus plugs may have acute exacerbation of asthma or poor treatment effect.At this time,we should pay attention to the existence of mucus plugs.Multidetector computed tomography can be used to identify and evaluate mucus plugs.This article briefly describes the generation of airway mucus,and introduces the formation mechanism,clinical characteristics,identification and scoring system of mucus plugs in asthmatic patients,and reviews the differential diagnosis and treatment of mucus plugs.

关 键 词：儿童 哮喘 黏蛋白 黏液栓 

分 类 号：R562.25[医药卫生—呼吸系统]