聚赖氨酸的生物医学领域应用现状  

Application status of polylysine polymer materials in biomedical field

作　　者：余波 郭一飞[1] YU Bo;GUO Yi-fei(Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100193,China)

机构地区：[1]中国医学科学院北京协和医学院药用植物研究所,北京100193

出　　处：《现代药物与临床》2022年第10期2377-2385,共9页Drugs & Clinic

基　　金：国家重点研发计划中医药现代化研究重点专项(2018YFC1706700)。

摘　　要：聚赖氨酸是一种天然的阳离子聚酰胺聚合物,具有良好的生物相容性和生物可降解性,因而在生物医学应用中显示出巨大的潜力。聚赖氨酸侧链上众多的氨基基团为功能化提供了结合位点,可形成众多衍生物。聚赖氨酸的高分子材料具有阳离子特性、生物相容性、无毒性和刺激响应特性,在生物医学领域中得到实际应用。介绍了聚赖氨酸在递送系统、生物黏合剂和生物纤维等生物医学领域的应用,希望挖掘聚赖氨酸类材料在生物医学应用方面巨大的潜力。Polylysine is a natural cationic polyamide polymer with good biocompatibility and biodegradability,which shows great potential in biomedical applications.A large number of amino groups in the polylysine side chain provide binding sites for functionalization and can form many derivatives.Poly-lysine-based polymer materials have water solubility,biocompatibility,nontoxicity,and stimulus response,and it has been widely used in the field of biomedicine.This paper introduces the application of polylysine in biomedical fields such as delivery systems,biological adhesives and biological fibers,hoping to tap the huge potential of polylysine materials in biomedical applications.

关 键 词：聚赖氨酸 递送系统 生物黏合剂 生物纤维 

分 类 号：R966[医药卫生—药理学]