姜黄素治疗帕金森病的作用机制研究进展  

Research progress on mechanism of curcumin in treatment of Parkinson’s disease

作　　者：赵志弘 王莉娟 李文惠 韩秋琴 ZHAO Zhi-hong;WANG Li-juan;LI Wen-hui;HAN Qiu-qin(School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China;Shanghai University of Medicine&Health Sciences Affiliated Zhoupu Hospital,Shanghai 201318,China;Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海理工大学健康科学与工程学院,上海200093 [2]上海健康医学院附属周浦医院,上海201318 [3]上海中医药大学,上海201203

出　　处：《现代药物与临床》2022年第10期2390-2396,共7页Drugs & Clinic

基　　金：上海市中央引导地方科技发展资金项目(YDZX20213100001002)。

摘　　要：帕金森病是好发于中老年人的神经退行性疾病。目前治疗帕金森病的常用药物是左旋多巴,但是患者在服用几年之后会出现一系列的不良反应。姜黄素是一种提取自姜黄科、天南星科等植物中的疏水性多酚类成分,在帕金森病的研究和治疗中展现出潜在的疗效。研究表明,姜黄素可以通过保护多巴胺能神经元、抗炎、抗氧化、抗细胞凋亡、抗线粒体损伤、调节自噬等多种途径在帕金森病中发挥神经保护作用。总结了姜黄素在帕金森病治疗中涉及到的不同作用机制,为进一步开发安全可靠的药物提供参考。Parkinson′s disease is a common neurodegenerative disease,which often occurs in the middle-aged and elderly.At present,the commonly used drug for the treatment of Parkinson′s disease is levodopa,but patients will experience a series of adverse reactions after taking it for several years.Curcumin is a kind of hydrophobic polyphenols from plants such as Curcuminaceae and Araceae,which shows potential curative effect in the research and treatment of Parkinson's disease.Studies have shown that curcumin can play a neuroprotective role in Parkinson′s disease by protecting dopaminergic neurons,anti-inflammatory,anti-oxidation,anti-apoptotic,anti-mitochondrial damage,and regulating autophagy and other pathways.This paper summarizes different mechanisms of curcumin in treatment of Parkinson′s disease,and provides a reference for the development of safe and reliable drugs in the future.

关 键 词：姜黄素 帕金森病 保护多巴胺能神经元 抗炎 抗氧化 抗细胞凋亡 

分 类 号：R285[医药卫生—中药学]