青蒿琥酯抗结直肠癌作用机制的研究进展  

Research progress on mechanism of artesunate against colorectal cancer

作　　者：唐祯 刘燕华[2] 李刚[1] 张增珠 TANG Zhen;LIU Yan-hua;LI Gang;ZHANG Zeng-zhu(Department of Pharmacy,The 908th Hospital of the PLA Joint Logistic Support Force,Nanchang 330001,China;School of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang 330004,China)

机构地区：[1]中国人民解放军联勤保障部队第908医院药剂科,江西南昌330001 [2]江西中医药大学药学院,江西南昌330004

出　　处：《现代药物与临床》2022年第10期2397-2401,共5页Drugs & Clinic

基　　金：江西省卫生计生委科技计划课题(20172214)。

摘　　要：结直肠癌是临床常见消化系统恶性肿瘤,具有较高的发病率和死亡率。青蒿琥酯是从菊科植物黄花蒿中提取的青蒿素衍生物,除抗疟作用外,可通过诱导细胞凋亡,抑制癌细胞增殖、侵袭和转移,抑制新血管形成,促进活性氧生成,抗炎,抗氧化应激反应发挥抗结直肠癌作用。探讨青蒿琥酯抗结直肠癌的作用机制,为青蒿琥酯的临床价值开发提供依据。Colorectal cancer is a common clinical malignant tumor of digestive system with high morbidity and mortality.Artesunate is an artemisinin derivative extracted from the Compositae plant Artemisia annua Linn.In addition to its antimalarial effect,artesunate can induce apoptosis,inhibit cancer cell proliferation,invasion,and metastasis,inhibit the formation of new blood vessels,and promote reactive oxygen species generation,anti-inflammatory,and anti-oxidative stress to exert anti-colorectal cancer effects.This article discusses the mechanism of artesunate against colorectal cancer,hoping to provide evidence for the clinical value of artesunate.

关 键 词：青蒿琥酯 结直肠癌 细胞凋亡 细胞增殖 新血管形成 活性氧 抗炎 氧化应激反应 

分 类 号：R977[医药卫生—药品]