双醛纤维素/聚乙烯醇复合水凝胶的制备及其性能  

Preparation and properties of dialdehyde cellulose/polyvinyl alcohol composite hydrogel

作　　者：杨明琰[1,2] 陈欣玥 张笑 管舒仪 蔡晓丹 张文博[1] 王福俊 李鑫[1] 王新平 YANG Mingyan;CHEN Xinyue;ZHANG Xiao;GUAN Shuyi;CAI Xiaodan;ZHANG Wenbo;WANG Fujun;LI Xin;WANG Xinping(School of Water Conservancy and Environment,Chang′an University,Xi′an 710061,China;Key Laboratory of Underground Hydrology and Ecological Effects in Arid Regions,Xi'an 710061,China;Shaanxi Institute of Geology and Mineral Resources Experiment CO.,LTD.,Xi'an 710054,China)

机构地区：[1]长安大学水利与环境学院,西安710061 [2]旱区地下水文与生态效应教育部重点实验室,西安710061 [3]陕西省地质矿产实验研究所有限公司,西安710054

出　　处：《复合材料学报》2022年第10期4889-4897,共9页Acta Materiae Compositae Sinica

基　　金：陕西省重点研发计划-社会发展项目(2021SF-443);长安大学2020年大学生创新创业训练计划专项建设经费和国家级项目的教育部财政资助经费(S202010710510)。

摘　　要：开发高性能功能性水凝胶并建立药物缓释模型对医用伤口创面材料的开发具有重要的意义。以小麦秸秆为原料通过对甲苯磺酸(p-TsOH)、高频超声、高碘酸盐氧化制备含木质素的生物交联剂双醛纤维素(2,3-dialdehyde cellulose,DAC);以DAC为交联剂与聚乙烯醇(PVA)通过羟醛缩合反应形成互穿网络结构的DAC/PVA复合水凝胶,研究了DAC含量对复合水凝胶的微观结构、吸水溶胀性能、抗压缩性能及热稳定性的影响;采用物理共混法包埋氨苄青霉素(AP)制备DAC/PVA-AP载药水凝胶并研究其药物释放过程、释放机制及抑菌作用。结果表明,DAC/PVA复合水凝胶的微观结构呈多孔3D网络立体结构,交联密度随DAC含量的增加而增加;复合水凝胶的含水量及溶胀率随着DAC含量的增加而减小,当DAC含量从0.8wt%增加至2.0wt%时,其吸水溶胀率从1 823.54%±13.89%降至1 105.41%±7.06%;在70%的应变下,1.0wt%DAC/PVA水凝胶的初始抗压强度达到5.765 MPa,抗压缩性能较强;经121℃高温湿热灭菌后,复合水凝胶均能保持完整的形貌,说明其具有优异的耐高温性能;DAC/PVA-AP载药水凝胶的释放模型符合Korsmeyer-Peppas模型,缓释溶液对测试细菌具有良好的抑菌作用。以小麦秸秆为原料制备的互穿网络结构DAC/PVA复合水凝胶具有力学性能好、能耐高温灭菌等优点,在伤口创面敷料等领域具有潜在的应用价值。Wheat straw was used as raw material to prepare lignin containing 2,3-dialdehyde cellulose(DAC)through sequential treatment of p-toluenesulfonic acid(p-TsOH), ultrasonication, sodium periodate oxidation.DAC was used as crosslinker to prepare 2,3-dialdehyde cellulose/polyvinyl alcohol(DAC/PVA) composite hydrogel through aldol condensation reaction. The microstructures, swelling properties, compression resistance and thermal stability of hydrogels were studied. Ampicillin(AP) was introduced to DAC/PVA composite hydrogel by embedding method to prepare DAC/PVA-AP hydrogel. Drug release process, release mechanism and antibacterial effect were studied as well. The results show that the microstructures of DAC/PVA composite hydrogels show a porous 3D network structure, and the crosslinking density increases with the increase of DAC. The water content and swelling property of composite hydrogel decrease with the increase of DAC. When the DAC concentration increases from 0.8wt% to 2.0wt%, the water absorption swelling rate decreases from 1 823.54%±13.89% to 1 105.41%±7.06%.The initial compressive strength of 1.0wt%DAC/PVA hydrogel reaches 5.765 MPa under 70% compression strain and present strong compression resistance. After sterilization at 121℃, the composite hydrogels can keep intact morphology, indicating that they have excellent high temperature resistance. The release model of DAC/PVA-AP hydrogel conforms to the Korsmeyer-Peppas model, and the sustained-release solution has a good antibacterial effect on the test bacteria. The DAC/PVA composite hydrogel prepared from wheat straw has a three-dimensional network structure, good mechanical properties and high temperature resistance, and has potential application the field of wound dressings.

关 键 词：生物交联剂 双醛纤维素(DAC) DAC/PVA复合水凝胶 抗压缩性能 耐高温性能 创面敷料 

分 类 号：TB332[一般工业技术—材料科学与工程]