Electroactive chitosan-aniline pentamer hydrogel for peripheral nerve regeneration  

作　　者：Deqiang MIAO Ya Li Zhongbing HUANG Yulin WANG Min DENG Xiaohui LI 

机构地区：[1]College of Biomedical Engineering,Sichuan University,Chengdu 610065,China

出　　处：《Frontiers of Materials Science》2022年第3期159-169,共11页材料学前沿（英文版）

基　　金：supported by National Key Research and Development Program of China(Grant No.2018YFC1106800);Sichuan Science and Technology Project(Grant No.2018JY0535).

摘　　要：Electroactive hydrogels could guide the regeneration of nerves and promote their functional recovery.An aniline pentamer-crosslinked chitosan(CS-AP)hydrogel with better electroactivity and degradation was fabricated by the carbodiimide method,and then injected into the repair site of sciatic nerve damage,with its gelation time,tensile strength,and conductivity reaching 35 min,5.02-6.69 MPa,and from 2.97×10^(-4) to 3.25×10^(-4) S-cm^(-1),respectively,due to the cross-linkage and well-distribution of AP.There was better cytocompativility of CS-AP hydrogel on nerve cells.The results of the in vivo repair indicated that CS-AP10 hydrogel induced the capillaries formation and the repair of sciatic nerve defect,and re-innervated gastrocnemius muscle in the CS-AP10 group were obviously better than other experimental groups,due to the electroactivity of CS-AP and its degradation into fragments.These results indicated the potential application of CS-AP hydrogel in the regeneration and function recovery of peripheral nerve injury.

关 键 词：peripheral nerve regeneration CHITOSAN aniline pentamer electroactive hydrogel capillary formation 

分 类 号：TB33[一般工业技术—材料科学与工程]