阻塞性睡眠呼吸暂停患者主客观鼻塞的相关性研究  

Correlation between subjective and objective nasal obstruction in patients with obstructive sleep apnea

作　　者：施云瀚 李彦如[1] 娄鸿飞[1] 王慧君 周怡 王蠡 韩德民[1] SHI Yunhan;LI Yanru;LOU Hongfei;WANG Huijun;ZHOU Yi;WANG Li;HAN Demin(Department of Otolaryngology Head and Neck Surgery,BeijingTongren Hospital,Capital Medical University,KeyLaboratoryof OtolaryngologyHeadandNeck Surgery(Capital Medical University),Ministryof Education,Beijing,100730,China)

机构地区：[1]首都医科大学附属北京同仁医院耳鼻咽喉头颈外科,耳鼻咽喉头颈科学教育部重点实验室(首都医科大学),北京100730

出　　处：《中国耳鼻咽喉头颈外科》2022年第9期547-551,共5页Chinese Archives of Otolaryngology-Head and Neck Surgery

基　　金：国家自然科学基金(81970866);北京市医院管理局“青苗”计划专项经费(QMS20190202)。

摘　　要：目的 探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者与正常人在主、客观鼻塞之间的差异和相关性,并分析可能的原因。方法 纳入82例OSAHS患者和43名健康受试者。使用鼻阻塞症状评估量表(nasal obstruction symptom evaluation,NOSE)和VAS评分量表评估主观鼻塞症状,鼻声反射仪、鼻阻力仪评估患者的客观鼻腔通气情况,比较两组在鼻塞评分、客观鼻腔通气检查和主客观鼻塞相关性之间的差异。结果 对照组呼吸暂停低通气指数(AHI)为(1.03±1.50)次/h,OSAHS组AHI为(39.33±23.03)次/h,两组间NOSE评分(30.06±20.5 vs 17.56±19.1,P<0.001)和主诉鼻塞(48.8% vs 20.9%,P=0.002)均有显著性差异。客观鼻腔通气检查结果在两组间无显著性差异(P均>0.05)。OSAHS组有中等的主客观鼻塞相关性并随疾病严重程度增加,对照组未发现明显主客观鼻塞的相关性。结论 OSAHS患者具有更严重的主观鼻塞症状,但客观的鼻腔通气检查未见显著性差异。OSAHS患者的主客观鼻塞相关性强于对照组,且与OSAHS严重程度有关。OBJECTIVE To investigate the differences and correlation between subjective and objective nasal obstruction in obstructive sleep apnea-hypopnea syndrome(OSAHS) patients and healthy controls,and analyzed the possible reasons.METHODS The study included 82 OSAHS patients and 43 healthy controls.The nasal obstruction symptom evaluation scale(NOSE scale) and the VAS were used to evaluate the subjective nasal obstruction symptoms,rhinomanometry and acoustic rhinometry were used to evaluate the objective nasal ventilation.The differences and correlation in subjective and objective nasal obstruction between two groups were compared.RESULTS There were 43 healthy controls[mean AHI=(1.03±1.50)times/h]and 82 OSAHS patients[mean AHI=(39.33±23.03)times/h]in this study.There was a significant difference in NOSE score(30.06±20.5 vs 17.56±19.1,P<0.001) and subjective nasal obstruction rate(48.8% vs 20.9%,P=0.002).The objective nasal ventilation examination results had no significant differences between the two groups(P>0.05).The OSAHS group had a moderate subjective-objective nasal obstruction correlation,which increased with severity;No significant correlation between subjective and objective nasal obstruction was found in the controls.CONCLUSION Compared with controls,OSAHS patients had more severe subjective nasal obstruction symptoms,but no significant difference was found in objective nasal ventilation examinations.The correlation between subjective-objective nasal obstruction in OSAHS patients was stronger than that in controls,and it was related to the severity of OSAHS.

关 键 词：睡眠呼吸暂停 阻塞性 鼻塞 鼻腔测压 鼻测量 声学 鼻阻塞症状评估量表 

分 类 号：R766[医药卫生—耳鼻咽喉科]