Efficient silencing of the multicopy DUX4 gene by ABE-mediated start codon mutation in human embryos  

作　　者：Yubing Liu Xinmei Lu Min Ye Ling Wang Rongxin Tang Zhiyong Yang Bongkoch Turathum Chenchen Liu Yujing Xue Menghua Wu Yannan Yang Ermeng Gao Di Zhang Feng Yang Keh-Kooi Kee Xingxu Huang Guanglei Li Ri-Cheng Chian 

机构地区：[1]Center for Reproductive Medicine,Tenth People's Hospital of Tongji University,301 Middle Yanchang Road,Shanghai 200072,China [2]Center for Reproductive Medicine,Zhongshan Hospital,Fudan University,180 Fenglin Road,Shanghai 200032,China [3]Center for Stem Cell Biology and Regenerative Medicine,Department of Basic Medical Sciences,School of Medicine,Tsinghua University,Beijing 100084,China [4]Department of Basic Medical Science,Faculty of Medicine Vajira Hospital,Navamindradhiraj University,Bangkok 10300,Thailand [5]School of Life Science and Technology,Shanghai Tech University,100 Haike Road,Pudong New Area,Shanghai 201210,China

出　　处：《Journal of Genetics and Genomics》2022年第10期982-985,共4页遗传学报（英文版）

基　　金：supported by the National Key R&D Program of China(2017YFC1002003);the project sponsored by the National Natural Science Foundation of China(31601197)。

摘　　要：The Dux gene plays an important role in mouse embryo development(De Iaco et al.,2017;Hendrickson et al.,2017;Whiddon et al.,2017).It participates in the maternal-to-zygotic transition(MTZ),which mainly includes maternal transcript degradation and zygotic genome activation(ZGA)and is the key process for embryonic development.Approximately 11-100 copies of the DUX4 gene form a tandem cluster in the human genome(Snider et al.,2009,2010).

关 键 词：development MATERNAL 

分 类 号：Q987[生物学—遗传学]