中药质量控制与评价创新方法研究进展及应用  

Research progress and application of innovative methods for quality control and evaluation of traditional Chinese medicine

作　　者：李天娇[1,2,3] 包永睿 王帅[1,2,3] 杨欣欣 肖雪[5] 王义明 孟宪生[1,2,3] 罗国安 LI Tian-jiao;BAO Yong-rui;WANG Shuai;YANG Xin-xin;XIAO Xue;WANG Yi-ming;MENG Xian-sheng;LUO Guo-an(College of Pharmacy,Liaoning University of Traditional Chinese Medicine,Dalian 116600,China;Liaoning Technical Innovation Center of Multi-dimensional Analysis of Traditional Chinese Medicine,Dalian 116600,China;Liaoning Modern Traditional Chinese Medicine Research and Engineering Laboratory,Dalian 116600,China;Department of Chemistry,Tsinghua University,Beijing 100084,China;Institute of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China)

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600 [2]辽宁省中药多维分析专业技术创新中心,辽宁大连116600 [3]辽宁省现代中药研究工程实验室,辽宁大连116600 [4]清华大学化学系,北京100084 [5]广东药科大学中医药研究院,广东广州510006

出　　处：《中草药》2022年第20期6319-6327,共9页Chinese Traditional and Herbal Drugs

基　　金：辽宁省中药药效物质组学与作用机制研究创新团队项目(LT2017015)。

摘　　要：中药质量是保证中药功效稳定性及应用安全性的基础,其规范化、标准化、现代化,是推动中药走向国际化的重要前提。近年来,围绕中药质量控制和评价体系建设及模式创新取得了突破,中药整合质量观、中药质量标志物等新思路、新模式的提出,引领了中药质控发展的新方向,涌现出了一系列中药质量评价创新技术与创新方法。拟从化学基准、化学基准与药理效应基准相结合、化学基准与生物效应基准相结合3个角度,从中药评价方面梳理近年来中药质控方法方面最新研究,系统阐述中药质量评价创新方法及其应用现状,探讨其未来发展趋势,以期为建立符合中药特色理论的质量控制体系提供拓展思路。The quality of traditional Chinese medicine is the basis to its efficacy stability and application safety.Thenormalization,standardization and modernization of quality is an important premise to promote the internationalization of traditional Chinese medicine. In recent years,breakthroughs have been made in the system and model of quality control and evaluation in traditional Chinese medicine. The proposal of new ideas such as intergrated quality control of TCMs and quality markers can guide new direction of the development of quality control in traditional Chinese medicine. Subsequently,a series of innovative technologies and innovative methods of quality evaluation in traditional Chinese medicine have emerged. This study inventoried the latest research on quality control methods in traditional Chinese medicine,systematically expounded the innovative methods and its application status from three perspectives of chemical benchmark,the combination of chemical benchmark and pharmacological effect benchmark,and the combination of chemical benchmark and biological effect benchmark,and discussed its future development trend. This paper provides an expanding idea for establishing a quality control system in line with the characteristic theory of traditional Chinese medicine.

关 键 词：中药 质量控制与评价 中药整合质量观 中药质量标志物 创新方法 应用现状 

分 类 号：R286[医药卫生—中药学]