中药单体成分防治糖尿病心血管并发症研究进展  

Research progress on prevention and treatment of diabetic cardiovascular complications by traditional Chinese medicine monomer

作　　者：贺一凡 周子烨 崖壮举 谢运勇 王斌[1,2] 刘继平 史永恒[1,2] HE Yi-fan;ZHOU Zi-ye;YA Zhuang-ju;XIE Yun-yong;WANG Bin;LIU Ji-ping;SHI Yong-heng(School of Pharmacy,Shaanxi University of Chinese Medicine,Xianyang 712046,China;Key Laboratory of Pharmacodynamics and Material Basis of Chinese Medicine,Shaanxi Administration of Traditional Chinese Medicine,Xianyang 712046,China)

机构地区：[1]陕西中医药大学药学院,陕西咸阳712046 [2]陕西省中医药管理局中药药效机制与物质基础重点研究室,陕西咸阳712046

出　　处：《中草药》2022年第19期6213-6226,共14页Chinese Traditional and Herbal Drugs

基　　金：陕西省教育厅专项科研计划项目(21JK0608);陕西省中医药管理局中医药科研项目(2021-ZZ-JC023);陕西中医药大学校级科研课题(2020GP32);陕西省自然科学基础研究计划项目(2019JQ-401)。

摘　　要：中药防治糖尿病心血管并发症具有积极的作用,从中提取分离的单体化合物往往具有较好的糖尿病心血管保护作用。主要检索了近5年国内外中药单体成分防治糖尿病心血管并发症的研究文献,整理了常用的有关中药活性单体类化合物,如黄酮类、环烯醚萜类、三萜皂苷类及生物碱类等化合物,综述了其发挥防治糖尿病心血管并发症的药理作用及机制,以期为糖尿病心血管并发症的防治和药物研发提供参考。Traditional Chinese medicine(TCM)plays a positive role in the prevention and treatment of cardiovascular complications of diabetes.Monomeric compounds extracted from TCM often exhibit good hypoglycemic and cardiovascular protection effects.In this paper,the literatures at home and abroad about TCM monomers on prevention and treatment of diabetic cardiovascular complications in recent 5 years were retrieved.The commonly used active compounds from TCM were sorted out and their structures were classified,such as flavonoids,iridoids,triterpenoid saponins and alkaloids.Furthermore,their pharmacological activities and basic mechanism of action were also reviewed,in order to provide effective reference for prevention and treatment and drug discovery of diabetic cardiovascular complications.

关 键 词：中药单体 糖尿病 心血管并发症 黄酮类化合物 环烯醚萜类化合物 三萜皂苷类化合物 生物碱 

分 类 号：R282.710.5[医药卫生—中药学]